Transforming growth factor-beta signaling in breast cancer

Ching Fang Chang, Reyhan Westbrook, Jun Ma, Deliang Cao

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations


Transforming growth factor-β (TGF-β) is a multifunctional polypeptide that regulates cell growth, differentiation, and extracellular matrix formation. Studies on genetically engineered animal models have demonstrated that TGF-β-mediated signaling pathway plays a critical role in both normal development and tumorigenesis of the breast. In pathogenesis of breast cancer, the role of TGF-β appears featured with growthinhibitory effects at early stages of carcinogenesis, but aggressive oncogenesis with transition to more advanced malignant states. The TGF-β signaling pathway is also tissue-context and ligand content-dependent. Therein, therapeutic modulation of TGF-β signaling may be a multifactorial event.

Original languageEnglish (US)
Pages (from-to)4393-4401
Number of pages9
JournalFrontiers in Bioscience
Issue number12
StatePublished - May 1 2007
Externally publishedYes


  • Animal model
  • Breast cancer
  • Cancer therapy
  • Mammary gland
  • Review
  • Smad protein
  • TGF-β ligand
  • TGF-β receptor
  • Tumor promotion
  • Tumor suppressor
  • Tumor-associated macrophages

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Immunology and Microbiology


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