Transforming Global Health by Improving the Science of Scale-Up

Margaret E. Kruk, Gavin Yamey, Sonia Y. Angell, Alix Beith, Daniel Cotlear, Frederico Guanais, Lisa Jacobs, Helen Saxenian, Cesar Victora, Eric Goosby

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


In its report Global Health 2035, the Commission on Investing in Health proposed that health investments can reduce mortality in nearly all low- and middle-income countries to very low levels, thereby averting 10 million deaths per year from 2035 onward. Many of these gains could be achieved through scale-up of existing technologies and health services. A key instrument to close this gap is policy and implementation research (PIR) that aims to produce generalizable evidence on what works to implement successful interventions at scale. Rigorously designed PIR promotes global learning and local accountability. Much greater national and global investments in PIR capacity will be required to enable the scaling of effective approaches and to prevent the recycling of failed ideas. Sample questions for the PIR research agenda include how to close the gap in the delivery of essential services to the poor, which population interventions for non-communicable diseases are most applicable in different contexts, and how to engage non-state actors in equitable provision of health services in the context of universal health coverage.

Original languageEnglish (US)
Article numbere1002360
JournalPLoS biology
Issue number3
StatePublished - Mar 2 2016
Externally publishedYes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Neuroscience(all)


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