Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression

Scott Koenig; Anthony J. Conley; Yambasu A. Brewah; Gary M. Jones; Simon Leath; Lynn J. Boots; Victoria Davey; Guiseppi Pantaleo; James F. Demarest; Charles Carter; Christine Wannebo; John R. Yannelli; Steven A. Rosenberg; H. Clifford Lane

doi:10.1038/nm0495-330

Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression

Scott Koenig, Anthony J. Conley, Yambasu A. Brewah, Gary M. Jones, Simon Leath, Lynn J. Boots, Victoria Davey, Guiseppi Pantaleo, James F. Demarest, Charles Carter, Christine Wannebo, John R. Yannelli, Steven A. Rosenberg, H. Clifford Lane

Research output: Contribution to journal › Article › peer-review

326 Scopus citations

Abstract

An HIV-1-seropositive volunteer was infused with an expanded autologous cytotoxic T lymphocyte (CTL) clone directed against the HIV-1 net protein. This clone was adoptively transferred to determine whether supplementing CTL activity could reduce viral load or improve clinical course. Unexpectedly, infusion was followed by a decline in circulating CD4⁺T cells and a rise in viral load. Some of the HIV isolates obtained from the plasma or CD4⁺cells of the patient were lacking the nef epitope. These results suggest that active CTL selection of viral variants could contribute to the pathogenesis of AIDS and that clinical progression can occur despite high levels of circulating HIV-1-specific CTLs.

Original language	English (US)
Pages (from-to)	330-336
Number of pages	7
Journal	Nature medicine
Volume	1
Issue number	4
DOIs	https://doi.org/10.1038/nm0495-330
State	Published - Apr 1995
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1038/nm0495-330

Cite this

Koenig, S., Conley, A. J., Brewah, Y. A., Jones, G. M., Leath, S., Boots, L. J., Davey, V., Pantaleo, G., Demarest, J. F., Carter, C., Wannebo, C., Yannelli, J. R., Rosenberg, S. A., & Lane, H. C. (1995). Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression. Nature medicine, 1(4), 330-336. https://doi.org/10.1038/nm0495-330

Koenig, S, Conley, AJ, Brewah, YA, Jones, GM, Leath, S, Boots, LJ, Davey, V, Pantaleo, G, Demarest, JF, Carter, C, Wannebo, C, Yannelli, JR, Rosenberg, SA & Lane, HC 1995, 'Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression', Nature medicine, vol. 1, no. 4, pp. 330-336. https://doi.org/10.1038/nm0495-330

@article{bddede3b1fcc4c32abd3f43952e2c3e6,

title = "Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression",

abstract = "An HIV-1-seropositive volunteer was infused with an expanded autologous cytotoxic T lymphocyte (CTL) clone directed against the HIV-1 net protein. This clone was adoptively transferred to determine whether supplementing CTL activity could reduce viral load or improve clinical course. Unexpectedly, infusion was followed by a decline in circulating CD4+T cells and a rise in viral load. Some of the HIV isolates obtained from the plasma or CD4+cells of the patient were lacking the nef epitope. These results suggest that active CTL selection of viral variants could contribute to the pathogenesis of AIDS and that clinical progression can occur despite high levels of circulating HIV-1-specific CTLs.",

author = "Scott Koenig and Conley, {Anthony J.} and Brewah, {Yambasu A.} and Jones, {Gary M.} and Simon Leath and Boots, {Lynn J.} and Victoria Davey and Guiseppi Pantaleo and Demarest, {James F.} and Charles Carter and Christine Wannebo and Yannelli, {John R.} and Rosenberg, {Steven A.} and Lane, {H. Clifford}",

year = "1995",

month = apr,

doi = "10.1038/nm0495-330",

language = "English (US)",

volume = "1",

pages = "330--336",

journal = "Nature medicine",

issn = "1078-8956",

publisher = "Nature Publishing Group",

number = "4",

}

TY - JOUR

T1 - Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression

AU - Koenig, Scott

AU - Conley, Anthony J.

AU - Brewah, Yambasu A.

AU - Jones, Gary M.

AU - Leath, Simon

AU - Boots, Lynn J.

AU - Davey, Victoria

AU - Pantaleo, Guiseppi

AU - Demarest, James F.

AU - Carter, Charles

AU - Wannebo, Christine

AU - Yannelli, John R.

AU - Rosenberg, Steven A.

AU - Lane, H. Clifford

PY - 1995/4

Y1 - 1995/4

N2 - An HIV-1-seropositive volunteer was infused with an expanded autologous cytotoxic T lymphocyte (CTL) clone directed against the HIV-1 net protein. This clone was adoptively transferred to determine whether supplementing CTL activity could reduce viral load or improve clinical course. Unexpectedly, infusion was followed by a decline in circulating CD4+T cells and a rise in viral load. Some of the HIV isolates obtained from the plasma or CD4+cells of the patient were lacking the nef epitope. These results suggest that active CTL selection of viral variants could contribute to the pathogenesis of AIDS and that clinical progression can occur despite high levels of circulating HIV-1-specific CTLs.

AB - An HIV-1-seropositive volunteer was infused with an expanded autologous cytotoxic T lymphocyte (CTL) clone directed against the HIV-1 net protein. This clone was adoptively transferred to determine whether supplementing CTL activity could reduce viral load or improve clinical course. Unexpectedly, infusion was followed by a decline in circulating CD4+T cells and a rise in viral load. Some of the HIV isolates obtained from the plasma or CD4+cells of the patient were lacking the nef epitope. These results suggest that active CTL selection of viral variants could contribute to the pathogenesis of AIDS and that clinical progression can occur despite high levels of circulating HIV-1-specific CTLs.

UR - http://www.scopus.com/inward/record.url?scp=0028969816&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028969816&partnerID=8YFLogxK

U2 - 10.1038/nm0495-330

DO - 10.1038/nm0495-330

M3 - Article

C2 - 7585062

AN - SCOPUS:0028969816

SN - 1078-8956

VL - 1

SP - 330

EP - 336

JO - Nature medicine

JF - Nature medicine

IS - 4

ER -

Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this