Transcription, splicing, and release: Are we there yet?

Ranjan Sen; Sebastian D. Fugmann

doi:10.1016/j.cell.2012.07.004

Transcription, splicing, and release: Are we there yet?

Ranjan Sen, Sebastian D. Fugmann

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A systematic analysis of LPS-induced gene expression in macrophages by Bhatt et al. demonstrates that inflammatory responses are governed primarily at the level of transcription initiation. Unexpectedly, full-length nascent RNAs that contain introns appear to accumulate on chromatin, presumably to complete processing, prior to release of functional mRNA for export to the cytoplasm.

Original language	English (US)
Pages (from-to)	241-243
Number of pages	3
Journal	Cell
Volume	150
Issue number	2
DOIs	https://doi.org/10.1016/j.cell.2012.07.004
State	Published - Jul 20 2012
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/j.cell.2012.07.004

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title = "Transcription, splicing, and release: Are we there yet?",

abstract = "A systematic analysis of LPS-induced gene expression in macrophages by Bhatt et al. demonstrates that inflammatory responses are governed primarily at the level of transcription initiation. Unexpectedly, full-length nascent RNAs that contain introns appear to accumulate on chromatin, presumably to complete processing, prior to release of functional mRNA for export to the cytoplasm.",

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AB - A systematic analysis of LPS-induced gene expression in macrophages by Bhatt et al. demonstrates that inflammatory responses are governed primarily at the level of transcription initiation. Unexpectedly, full-length nascent RNAs that contain introns appear to accumulate on chromatin, presumably to complete processing, prior to release of functional mRNA for export to the cytoplasm.

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Transcription, splicing, and release: Are we there yet?

Abstract

ASJC Scopus subject areas

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