Transcription meets metabolism in neurodegeneration

Christopher A. Ross; Leslie Michels Thompson

doi:10.1038/nm1106-1239

Transcription meets metabolism in neurodegeneration

Christopher A. Ross, Leslie Michels Thompson

School of Medicine

Research output: Contribution to journal › Short survey › peer-review

25 Scopus citations

Abstract

A molecular basis for the metabolic abnormalities observed in Huntington disease is emerging. Transcription of a key mitochondrial regulator, PGC-1α, is dysregulated by mutant huntingtin, leading to oxidative stress and excitotoxicity. The findings dovetail with previous work implicating aberrant transcription in Huntington disease, and have implications for related conditions such as Parkinson disease.

Original language	English (US)
Pages (from-to)	1239-1241
Number of pages	3
Journal	Nature medicine
Volume	12
Issue number	11
DOIs	https://doi.org/10.1038/nm1106-1239
State	Published - Nov 1 2006

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1038/nm1106-1239

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title = "Transcription meets metabolism in neurodegeneration",

abstract = "A molecular basis for the metabolic abnormalities observed in Huntington disease is emerging. Transcription of a key mitochondrial regulator, PGC-1α, is dysregulated by mutant huntingtin, leading to oxidative stress and excitotoxicity. The findings dovetail with previous work implicating aberrant transcription in Huntington disease, and have implications for related conditions such as Parkinson disease.",

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AB - A molecular basis for the metabolic abnormalities observed in Huntington disease is emerging. Transcription of a key mitochondrial regulator, PGC-1α, is dysregulated by mutant huntingtin, leading to oxidative stress and excitotoxicity. The findings dovetail with previous work implicating aberrant transcription in Huntington disease, and have implications for related conditions such as Parkinson disease.

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Transcription meets metabolism in neurodegeneration

Abstract

ASJC Scopus subject areas

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