TY - JOUR
T1 - Transcatheter arterial chemoembolization of liver tumors
T2 - Effects of embolization protocol on injectable volume of chemotherapy and subsequent arterial patency
AU - Geschwind, Jean Francois H.
AU - Ramsey, Douglas E.
AU - Cleffken, Berry
AU - Van der Wal, B. C.H.
AU - Kobeiter, Hicham
AU - Juluru, Krishna
AU - Hartnell, George G.
AU - Choti, Michael A.
PY - 2003/3
Y1 - 2003/3
N2 - The purpose of this study was to determine whether transcatheter arterial chemoembolization (TACE) protocol affects the total volume of chemotherapy injected into the liver as well as subsequent arterial patency. A total of 160 patients with primary or secondary liver cancer were treated with 3 different chemoembolization protocols at a single institution. Data were analyzed retrospectively. Group 1 (n = 36) consisted of slurry of chemotherapy, oil and polyvinyl alcohol particles (PVA), group 2 (n = 91), chemotherapy and oil followed by PVA, and group 3 (n = 33), chemotherapy and oil followed by Gelfoam pledgets. The total volume of chemotherapy injected into the liver was recorded. Arterial patency was determined during subsequent chemoembolizations. The mean percentage of total intended chemotherapy dose administered was 54.6% for group 1, 75.3% for group 2, and 80.6% for group 3. Arterial patency at follow-up angiography was 56% for group 1, 74% for group 2, and 81% for group 3. The slurry protocol (group 1) significantly reduced arterial patency and injectable volume of chemotherapy during TACE.
AB - The purpose of this study was to determine whether transcatheter arterial chemoembolization (TACE) protocol affects the total volume of chemotherapy injected into the liver as well as subsequent arterial patency. A total of 160 patients with primary or secondary liver cancer were treated with 3 different chemoembolization protocols at a single institution. Data were analyzed retrospectively. Group 1 (n = 36) consisted of slurry of chemotherapy, oil and polyvinyl alcohol particles (PVA), group 2 (n = 91), chemotherapy and oil followed by PVA, and group 3 (n = 33), chemotherapy and oil followed by Gelfoam pledgets. The total volume of chemotherapy injected into the liver was recorded. Arterial patency was determined during subsequent chemoembolizations. The mean percentage of total intended chemotherapy dose administered was 54.6% for group 1, 75.3% for group 2, and 80.6% for group 3. Arterial patency at follow-up angiography was 56% for group 1, 74% for group 2, and 81% for group 3. The slurry protocol (group 1) significantly reduced arterial patency and injectable volume of chemotherapy during TACE.
KW - Angiography
KW - Arteries
KW - Blood supply
KW - Chemotherapeutic embolization
KW - Embolic material
KW - Liver neoplasms
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UR - http://www.scopus.com/inward/citedby.url?scp=0042267397&partnerID=8YFLogxK
U2 - 10.1007/s00270-002-2524-6
DO - 10.1007/s00270-002-2524-6
M3 - Article
C2 - 12616414
AN - SCOPUS:0042267397
SN - 0174-1551
VL - 26
SP - 111
EP - 117
JO - Cardiovascular and interventional radiology
JF - Cardiovascular and interventional radiology
IS - 2
ER -