TY - JOUR
T1 - Trametinib-induced Left Ventricular Dysfunction in a Child with Relapsed Neuroblastoma
AU - Modak, Shakeel
AU - Asante-Korang, Alfred
AU - Steinherz, Laurel J.
AU - Grana, Nanette
N1 - Publisher Copyright:
© 2015 Wolters Kluwer Health, Inc. All rights reserved.
Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 2015/8/6
Y1 - 2015/8/6
N2 - The MEK inhibitor trametinib is globally approved for metastatic melanoma harboring BRAF mutations. There are no reports thus far on its use in children. Exome sequencing on a relapsed tumor sample from an 11-year-old male with progressive, multiply relapsed stage 4 neuroblastoma revealed NRASQ61K mutation. After demonstration of normal cardiac function, he was started on oral trametinib. On day 13 of treatment, echocardiogram showed moderate left ventricular dysfunction. Trametinib was discontinued on day 15 and oral lisinopril was started. Left ventricular function recovered to baseline 37 days after discontinuing trametinib. However, neuroblastoma showed further progression.
AB - The MEK inhibitor trametinib is globally approved for metastatic melanoma harboring BRAF mutations. There are no reports thus far on its use in children. Exome sequencing on a relapsed tumor sample from an 11-year-old male with progressive, multiply relapsed stage 4 neuroblastoma revealed NRASQ61K mutation. After demonstration of normal cardiac function, he was started on oral trametinib. On day 13 of treatment, echocardiogram showed moderate left ventricular dysfunction. Trametinib was discontinued on day 15 and oral lisinopril was started. Left ventricular function recovered to baseline 37 days after discontinuing trametinib. However, neuroblastoma showed further progression.
KW - cardiomyopathy
KW - neuroblastoma
KW - trametinib
KW - treatment-related cardiotoxicity
UR - http://www.scopus.com/inward/record.url?scp=84938582830&partnerID=8YFLogxK
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U2 - 10.1097/MPH.0000000000000364
DO - 10.1097/MPH.0000000000000364
M3 - Article
C2 - 26181424
AN - SCOPUS:84938582830
SN - 1077-4114
VL - 37
SP - e381-e383
JO - Journal of Pediatric Hematology/Oncology
JF - Journal of Pediatric Hematology/Oncology
IS - 6
ER -