Toxicodynamics and long-term toxicity of the recreational drug, 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy')

G. A. Ricaurte; U. D. McCann; Z. Szabo; U. Scheffel

doi:10.1016/S0378-4274(99)00216-7

Toxicodynamics and long-term toxicity of the recreational drug, 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy')

G. A. Ricaurte, U. D. McCann, Z. Szabo, U. Scheffel

School of Medicine

Research output: Contribution to journal › Article › peer-review

97 Scopus citations

Abstract

The recreational drug, (±)3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy'), is a potent serotonin (5-HT) neurotoxin in animals. Whether humans who use MDMA incur 5-HT neural injury is unknown. The present studies utilized positron emission tomography (PET) in conjunction with the 5-HT transporter ligand, [¹¹C]McN-5652 to assess the status of brain 5-HT neurons in human MDMA users. Like nonhuman primates treated with neurotoxic doses of MDMA, humans with a history of MDMA use showed lasting decrements in global brain [¹¹C]McN-5652 binding, with decreases in [¹¹C]McN-5652 binding positively correlated to the extent of previous MDMA use. These results suggest that human MDMA use results in brain 5-HT neurotoxicity. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original language	English (US)
Pages (from-to)	143-146
Number of pages	4
Journal	Toxicology Letters
Volume	112-113
DOIs	https://doi.org/10.1016/S0378-4274(99)00216-7
State	Published - Mar 15 2000

Keywords

3,4-Methylenedioxy-methamphetamine
Amphetamines
Neurotoxicity
PET
Serotonin
Transporters

ASJC Scopus subject areas

Toxicology

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10.1016/S0378-4274(99)00216-7

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title = "Toxicodynamics and long-term toxicity of the recreational drug, 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy')",

abstract = "The recreational drug, (±)3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy'), is a potent serotonin (5-HT) neurotoxin in animals. Whether humans who use MDMA incur 5-HT neural injury is unknown. The present studies utilized positron emission tomography (PET) in conjunction with the 5-HT transporter ligand, [11C]McN-5652 to assess the status of brain 5-HT neurons in human MDMA users. Like nonhuman primates treated with neurotoxic doses of MDMA, humans with a history of MDMA use showed lasting decrements in global brain [11C]McN-5652 binding, with decreases in [11C]McN-5652 binding positively correlated to the extent of previous MDMA use. These results suggest that human MDMA use results in brain 5-HT neurotoxicity. Copyright (C) 2000 Elsevier Science Ireland Ltd.",

keywords = "3,4-Methylenedioxy-methamphetamine, Amphetamines, Neurotoxicity, PET, Serotonin, Transporters",

author = "Ricaurte, {G. A.} and McCann, {U. D.} and Z. Szabo and U. Scheffel",

note = "Funding Information: This work was supported by PHS grants DA05707, DA06275 (G.A. Ricaurte) and the NIMH IRP (U.D. McCann). ",

year = "2000",

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doi = "10.1016/S0378-4274(99)00216-7",

language = "English (US)",

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AU - Ricaurte, G. A.

AU - McCann, U. D.

AU - Szabo, Z.

AU - Scheffel, U.

N1 - Funding Information: This work was supported by PHS grants DA05707, DA06275 (G.A. Ricaurte) and the NIMH IRP (U.D. McCann).

PY - 2000/3/15

Y1 - 2000/3/15

N2 - The recreational drug, (±)3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy'), is a potent serotonin (5-HT) neurotoxin in animals. Whether humans who use MDMA incur 5-HT neural injury is unknown. The present studies utilized positron emission tomography (PET) in conjunction with the 5-HT transporter ligand, [11C]McN-5652 to assess the status of brain 5-HT neurons in human MDMA users. Like nonhuman primates treated with neurotoxic doses of MDMA, humans with a history of MDMA use showed lasting decrements in global brain [11C]McN-5652 binding, with decreases in [11C]McN-5652 binding positively correlated to the extent of previous MDMA use. These results suggest that human MDMA use results in brain 5-HT neurotoxicity. Copyright (C) 2000 Elsevier Science Ireland Ltd.

AB - The recreational drug, (±)3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy'), is a potent serotonin (5-HT) neurotoxin in animals. Whether humans who use MDMA incur 5-HT neural injury is unknown. The present studies utilized positron emission tomography (PET) in conjunction with the 5-HT transporter ligand, [11C]McN-5652 to assess the status of brain 5-HT neurons in human MDMA users. Like nonhuman primates treated with neurotoxic doses of MDMA, humans with a history of MDMA use showed lasting decrements in global brain [11C]McN-5652 binding, with decreases in [11C]McN-5652 binding positively correlated to the extent of previous MDMA use. These results suggest that human MDMA use results in brain 5-HT neurotoxicity. Copyright (C) 2000 Elsevier Science Ireland Ltd.

KW - 3,4-Methylenedioxy-methamphetamine

KW - Amphetamines

KW - Neurotoxicity

KW - PET

KW - Serotonin

KW - Transporters

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Toxicodynamics and long-term toxicity of the recreational drug, 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy')

Abstract

Keywords

ASJC Scopus subject areas

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