TY - JOUR
T1 - Toxic-Therapeutic Ratio of Sodium Cyanate
AU - Charache, Samuel
AU - Duffy, Thomas P.
AU - Jander, Nancy
AU - Scott, Jean C.
AU - Bedine, Marshall
AU - Morrell, Roger
PY - 1975/8
Y1 - 1975/8
N2 - Six patients with sickle cell anemia were treated with sodium cyanate (30 mg/ kg/day). In four, treatment was stopped because of definite or suspected toxicity, and no improvement was seen in the other two. Most alarming was the sudden development of a peripheral motor neuropathy in a patient whose red blood cells contained less than 0.6 mols NCO /mol of hemoglobin; six months after treatment was stopped, function had not completely returned in this patient. Safe oral dosage regimens may not be effective, but extracorporeal treatment of sickle cells with cyanate, or other compounds, might circumvent that problem.
AB - Six patients with sickle cell anemia were treated with sodium cyanate (30 mg/ kg/day). In four, treatment was stopped because of definite or suspected toxicity, and no improvement was seen in the other two. Most alarming was the sudden development of a peripheral motor neuropathy in a patient whose red blood cells contained less than 0.6 mols NCO /mol of hemoglobin; six months after treatment was stopped, function had not completely returned in this patient. Safe oral dosage regimens may not be effective, but extracorporeal treatment of sickle cells with cyanate, or other compounds, might circumvent that problem.
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U2 - 10.1001/archinte.1975.00330080045007
DO - 10.1001/archinte.1975.00330080045007
M3 - Article
C2 - 1156065
AN - SCOPUS:84942506717
SN - 0003-9926
VL - 135
SP - 1043
EP - 1047
JO - Archives of internal medicine
JF - Archives of internal medicine
IS - 8
ER -