Toxic neuropathy in patients with pre-existing neuropathy

V. Chaudhry, M. Chaudhry, T. O. Crawford, E. Simmons-O'Brien, J. W. Griffin

Research output: Contribution to journalArticlepeer-review

144 Scopus citations


The authors report significant worsening of a pre-existing neuropathy in six patients who received "non-toxic" dosages of known neurotoxic agents. Before treatment, baseline total neuropathy score (TNS) averaged 9.5 (range 0 to 19). After chemotherapy (Taxol [125 to 175 mg/m2 x 4]; vincristine [2 to 5 mg]; cisplatin [40 mg/m2 x 8]; and thalidomide [60 g]), the TNS averaged 22 (range 13 to 29). The authors conclude that functionally disabling toxic neuropathy can occur in patients with pre-existing neuropathy at standard doses.

Original languageEnglish (US)
Pages (from-to)337-340
Number of pages4
Issue number2
StatePublished - Jan 28 2003

ASJC Scopus subject areas

  • Clinical Neurology


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