Towards a better understanding of QT interval variability

Larisa G. Tereshchenko, Ronald D. Berger

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


The International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) Guideline E14 recommends ‘Thorough QT Study’ as a standard assessment of drug-induced QT interval prolongation. At the same time, the value of drug-induced QTc prolongation as a surrogate marker for risk of life-threatening polymorphic ventricular tachycardia known as torsades des pointes remains controversial. Beat-to-beat variability of QT interval was recently proposed as an alternative metric. The following review addresses mechanisms of beat-to-beat QT variability, methods of QT interval variability measurements, and its prognostic value in clinical studies.

Original languageEnglish (US)
Pages (from-to)245-251
Number of pages7
JournalTherapeutic Advances in Drug Safety
Issue number6
StatePublished - Dec 2011


  • QT interval
  • QT variability
  • drug safety
  • ventricular tachyarrhythmias

ASJC Scopus subject areas

  • Pharmacology (medical)


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