Abstract
Nineteen patients with cutaneous T-cell lymphoma (CTCL) limited to the skin and/or lymph nodes were treated at Hahnemann University with a combination of total skin electron beam and total nodal irradiation (TSEB + TNI). The patients were classified as Stage Ib (1 patient), Stage IIa (8 patients), Stage IIb (5 patients), and Stage IVa (5 patients). Treatment resulted in a complete response in 100% ( 14 14) of patients with Stage lb, IIa, and Ilb disease, and a CR in 60% ( 3 5) of patients with Stage IVa disease. The Stage Ib and IIa patients had an overall survival of 100% and a disease-free survival of 44% at 6 years. Four of the five patients with Stage IIb CTCL relapsed within 3 months after completing TSEB + TNI with an overall survival in the group of 40% at 5 years. The Stage IVa patients all relapsed within 7 months and died of their disease within 50 months of completing treatment. The acute effects of TSEB + TNI were well tolerated, but three patients developed second malignancy (lung, kidney and skin) and one patient developed myelodysplasia, possibly the result of radiotherapy.
Original language | English (US) |
---|---|
Pages (from-to) | 809-813 |
Number of pages | 5 |
Journal | International Journal of Radiation Oncology, Biology, Physics |
Volume | 20 |
Issue number | 4 |
DOIs | |
State | Published - 1991 |
Externally published | Yes |
Keywords
- Cutaneous T-cell lymphoma
- Total nodal irradiation
- Total skin electron beam
ASJC Scopus subject areas
- Oncology
- Radiology Nuclear Medicine and imaging
- Radiation