Topology-preserving tissue classification of magnetic resonance brain images

Pierre Louis Bazin, Dzung L. Pham

Research output: Contribution to journalArticlepeer-review

97 Scopus citations


This paper presents a new framework for multiple object segmentation in medical images that respects the topological properties and relationships of structures as given by a template. The technique, known as topology-preserving, anatomy-driven segmentation (TOADS), combines advantages of statistical tissue classification, topology-preserving fast marching methods, and image registration to enforce object-level relationships with little constraint over the geometry. When applied to the problem of brain segmentation, it directly provides a cortical surface with spherical topology while segmenting the main cerebral structures. Validation on simulated and real images characterises the performance of the algorithm with regard to noise, inhomogeneities, and anatomical variations.

Original languageEnglish (US)
Pages (from-to)487-496
Number of pages10
JournalIEEE transactions on medical imaging
Issue number4
StatePublished - Apr 2007
Externally publishedYes


  • Brain anatomy
  • Digital topology
  • Image segmentation
  • Magnetic resonance imaging
  • Tissue classification

ASJC Scopus subject areas

  • Software
  • Radiological and Ultrasound Technology
  • Computer Science Applications
  • Electrical and Electronic Engineering


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