Topoisomerases in kinetoplastids

Christian Burri; Annette L. Bodley; Theresa A. Shapiro

doi:10.1016/0169-4758(96)10017-X

Topoisomerases in kinetoplastids

Christian Burri, Annette L. Bodley, Theresa A. Shapiro

School of Medicine

Research output: Contribution to journal › Review article › peer-review

34 Scopus citations

Abstract

Topoisomerases are enzymes that mediate topological changes in DNA that are essential for nucleic acid biosynthesis and for cell survival. The kinetoplastid protozoa, which include pathogenic trypanosomes and Leishmania, have yielded an interesting variety of purified topoisomerase activities as well as several topoisomerase genes. In these parasites, topoisomerases are involved in the metabolism of both nuclear and mitochondrial (kinetoplast) DNA. In this review, Christian Burri, Annette Bodley and Theresa Shapiro summarize what is known about topoisomerases in kinetoplastids, and consider the intriguing possibility that these enzymes may act as valuable antiparasite drug targets.

Original language	English (US)
Pages (from-to)	226-231
Number of pages	6
Journal	Parasitology Today
Volume	12
Issue number	6
DOIs	https://doi.org/10.1016/0169-4758(96)10017-X
State	Published - Jun 1996

ASJC Scopus subject areas

Parasitology

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10.1016/0169-4758(96)10017-X

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abstract = "Topoisomerases are enzymes that mediate topological changes in DNA that are essential for nucleic acid biosynthesis and for cell survival. The kinetoplastid protozoa, which include pathogenic trypanosomes and Leishmania, have yielded an interesting variety of purified topoisomerase activities as well as several topoisomerase genes. In these parasites, topoisomerases are involved in the metabolism of both nuclear and mitochondrial (kinetoplast) DNA. In this review, Christian Burri, Annette Bodley and Theresa Shapiro summarize what is known about topoisomerases in kinetoplastids, and consider the intriguing possibility that these enzymes may act as valuable antiparasite drug targets.",

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note = "Funding Information: We thank Paul Englund and Donna Klinedinst for reading this manuscript. Work in our laboratory was supported by US Public Health Service grant AI-28855, by a Scholar Award in Experimental Therapeutics from the Burroughs Wellcome Fund (TS), by the Swiss National Research Foundation (CB). the Ciba Jubilaeums Foundation (CB). and the Theodor Engelmann Foundation (CB),",

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AU - Burri, Christian

AU - Bodley, Annette L.

AU - Shapiro, Theresa A.

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N2 - Topoisomerases are enzymes that mediate topological changes in DNA that are essential for nucleic acid biosynthesis and for cell survival. The kinetoplastid protozoa, which include pathogenic trypanosomes and Leishmania, have yielded an interesting variety of purified topoisomerase activities as well as several topoisomerase genes. In these parasites, topoisomerases are involved in the metabolism of both nuclear and mitochondrial (kinetoplast) DNA. In this review, Christian Burri, Annette Bodley and Theresa Shapiro summarize what is known about topoisomerases in kinetoplastids, and consider the intriguing possibility that these enzymes may act as valuable antiparasite drug targets.

AB - Topoisomerases are enzymes that mediate topological changes in DNA that are essential for nucleic acid biosynthesis and for cell survival. The kinetoplastid protozoa, which include pathogenic trypanosomes and Leishmania, have yielded an interesting variety of purified topoisomerase activities as well as several topoisomerase genes. In these parasites, topoisomerases are involved in the metabolism of both nuclear and mitochondrial (kinetoplast) DNA. In this review, Christian Burri, Annette Bodley and Theresa Shapiro summarize what is known about topoisomerases in kinetoplastids, and consider the intriguing possibility that these enzymes may act as valuable antiparasite drug targets.

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Topoisomerases in kinetoplastids

Abstract

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