Toll-like receptors (TLR2 and TLR4) recognize polysaccharides of Pseudallescheria boydii cell wall

Rodrigo Tinoco Figueiredo; Vera Carolina B. Bittencourt; Lívia Cristina L. Lopes; Guilherme Sassaki; Eliana Barreto-Bergter

doi:10.1016/j.carres.2012.02.028

Toll-like receptors (TLR2 and TLR4) recognize polysaccharides of Pseudallescheria boydii cell wall

Rodrigo Tinoco Figueiredo
, Vera Carolina B. Bittencourt
, Lívia Cristina L. Lopes
, Guilherme Sassaki
, Eliana Barreto-Bergter

Research output: Contribution to journal › Article › peer-review

Abstract

Pseudallescheria boydii is an opportunistic fungus widespread in the environment, and has recently emerged as an agent of localized as well as disseminated infections in both immunocompromised and immunocompetent hosts. The host response to fungi is in part dependent on the activation of evolutionary conserved receptors including Toll-like receptors and phagocytic receptors. This review will discuss the isolation and structural characterization of α-glucans and rhamnomannans from P. boydii cell wall and their roles in the induction of innate immune response.

Original language	English (US)
Pages (from-to)	260-264
Number of pages	5
Journal	Carbohydrate Research
Volume	356
DOIs	https://doi.org/10.1016/j.carres.2012.02.028
State	Published - Jul 15 2012
Externally published	Yes

Keywords

Innate immunity
Pseudallescheria boydii
Rhamnomannans
Scedosporium apiospermum
Toll-like receptors
α-Glucans

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Organic Chemistry

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10.1016/j.carres.2012.02.028

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@article{5fe5c964e021494eb1656d71716bec31,

title = "Toll-like receptors (TLR2 and TLR4) recognize polysaccharides of Pseudallescheria boydii cell wall",

abstract = "Pseudallescheria boydii is an opportunistic fungus widespread in the environment, and has recently emerged as an agent of localized as well as disseminated infections in both immunocompromised and immunocompetent hosts. The host response to fungi is in part dependent on the activation of evolutionary conserved receptors including Toll-like receptors and phagocytic receptors. This review will discuss the isolation and structural characterization of α-glucans and rhamnomannans from P. boydii cell wall and their roles in the induction of innate immune response.",

keywords = "Innate immunity, Pseudallescheria boydii, Rhamnomannans, Scedosporium apiospermum, Toll-like receptors, α-Glucans",

author = "Figueiredo, \{Rodrigo Tinoco\} and Bittencourt, \{Vera Carolina B.\} and Lopes, \{L{\'i}via Cristina L.\} and Guilherme Sassaki and Eliana Barreto-Bergter",

note = "Funding Information: The work was supported by the Conselho Nacional de Desenvolvimento Cient{\'i}fico e Tecnol{\'o}gico (CNPq), Coordena{\c c}{\~a}o de Aperfei{\c c}oamento de Pessoal de Ensino Superior (CAPES), Funda{\c c}{\~a}o de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ), Programa de N{\'u}cleos de Excel{\^e}ncia (Pronex), and Universidade Federal do Rio de Janeiro (UFRJ).",

year = "2012",

month = jul,

day = "15",

doi = "10.1016/j.carres.2012.02.028",

language = "English (US)",

volume = "356",

pages = "260--264",

journal = "Carbohydrate Research",

issn = "0008-6215",

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TY - JOUR

T1 - Toll-like receptors (TLR2 and TLR4) recognize polysaccharides of Pseudallescheria boydii cell wall

AU - Figueiredo, Rodrigo Tinoco

AU - Bittencourt, Vera Carolina B.

AU - Lopes, Lívia Cristina L.

AU - Sassaki, Guilherme

AU - Barreto-Bergter, Eliana

N1 - Funding Information: The work was supported by the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Ensino Superior (CAPES), Fundação de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ), Programa de Núcleos de Excelência (Pronex), and Universidade Federal do Rio de Janeiro (UFRJ).

PY - 2012/7/15

Y1 - 2012/7/15

N2 - Pseudallescheria boydii is an opportunistic fungus widespread in the environment, and has recently emerged as an agent of localized as well as disseminated infections in both immunocompromised and immunocompetent hosts. The host response to fungi is in part dependent on the activation of evolutionary conserved receptors including Toll-like receptors and phagocytic receptors. This review will discuss the isolation and structural characterization of α-glucans and rhamnomannans from P. boydii cell wall and their roles in the induction of innate immune response.

AB - Pseudallescheria boydii is an opportunistic fungus widespread in the environment, and has recently emerged as an agent of localized as well as disseminated infections in both immunocompromised and immunocompetent hosts. The host response to fungi is in part dependent on the activation of evolutionary conserved receptors including Toll-like receptors and phagocytic receptors. This review will discuss the isolation and structural characterization of α-glucans and rhamnomannans from P. boydii cell wall and their roles in the induction of innate immune response.

KW - Innate immunity

KW - Pseudallescheria boydii

KW - Rhamnomannans

KW - Scedosporium apiospermum

KW - Toll-like receptors

KW - α-Glucans

UR - https://www.scopus.com/pages/publications/84862326530

UR - https://www.scopus.com/pages/publications/84862326530#tab=citedBy

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DO - 10.1016/j.carres.2012.02.028

M3 - Article

C2 - 22507831

AN - SCOPUS:84862326530

SN - 0008-6215

VL - 356

SP - 260

EP - 264

JO - Carbohydrate Research

JF - Carbohydrate Research

ER -

Toll-like receptors (TLR2 and TLR4) recognize polysaccharides of Pseudallescheria boydii cell wall

Abstract

Keywords

ASJC Scopus subject areas

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