Toll-like receptor signaling in neural plasticity and disease

Eitan Okun, Kathleen J. Griffioen, Mark P. Mattson

Research output: Contribution to journalArticlepeer-review

324 Scopus citations


Toll-like receptors (TLRs) are a family of innate immune system receptors that respond to pathogen-derived and tissue damage-related ligands. TLR signaling in immune cells, glia and neurons can play roles in the pathogenesis of stroke, Alzheimer's disease (AD) and multiple sclerosis (MS). Recent findings suggest that TLR signaling also influences multiple dynamic processes in the developing and adult central nervous system including neurogenesis, axonal growth and structural plasticity. In addition, TLRs are implicated in the regulation of behaviors including learning, memory and anxiety. This review describes recently discovered and unexpected roles for TLRs in neuroplasticity, and the implications of these findings for future basic and translational research studies.

Original languageEnglish (US)
Pages (from-to)269-281
Number of pages13
JournalTrends in Neurosciences
Issue number5
StatePublished - May 2011
Externally publishedYes

ASJC Scopus subject areas

  • General Neuroscience


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