Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis

Matthew D. Neal; Chhinder P. Sodhi; Hongpeng Jia; Mitchell Dyer; Charlotte E. Egan; Ibrahim Yazji; Misty Good; Amin Afrazi; Ryan Marino; Dennis Slagle; Congrong Ma; Maria F. Branca; Thomas Prindle; Zachary Grant; John Ozolek; David J. Hackam

doi:10.1074/jbc.M112.375881

Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis

Matthew D. Neal
, Chhinder P. Sodhi
, Hongpeng Jia
, Mitchell Dyer
, Charlotte E. Egan
, Ibrahim Yazji
, Misty Good
, Amin Afrazi
, Ryan Marino
, Dennis Slagle
, Congrong Ma
, Maria F. Branca
, Thomas Prindle
, Zachary Grant
, John Ozolek
, David J. Hackam

Research output: Contribution to journal › Article › peer-review

114 Scopus citations

Abstract

Background: Factors that regulate intestinal stem cell (ISC) proliferation and apoptosis are unknown. Results: Toll-like receptor 4 (TLR4) is expressed on ISCs and regulates their proliferation and apoptosis, which is critical in the pathogenesis of necrotizing enterocolitis (NEC). Conclusion: TLR4 regulates ISC proliferation and apoptosis. Significance: This is the first study showing that ISC regulation by microbial receptors contributes to NEC pathogenesis.

Original language	English (US)
Pages (from-to)	37296-37308
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	287
Issue number	44
DOIs	https://doi.org/10.1074/jbc.M112.375881
State	Published - Oct 26 2012
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Neal, M. D., Sodhi, C. P., Jia, H., Dyer, M., Egan, C. E., Yazji, I., Good, M., Afrazi, A., Marino, R., Slagle, D., Ma, C., Branca, M. F., Prindle, T., Grant, Z., Ozolek, J., & Hackam, D. J. (2012). Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis. Journal of Biological Chemistry, 287(44), 37296-37308. https://doi.org/10.1074/jbc.M112.375881

Neal, MD, Sodhi, CP , Jia, H, Dyer, M, Egan, CE, Yazji, I, Good, M, Afrazi, A, Marino, R, Slagle, D, Ma, C, Branca, MF, Prindle, T, Grant, Z, Ozolek, J & Hackam, DJ 2012, 'Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis', Journal of Biological Chemistry, vol. 287, no. 44, pp. 37296-37308. https://doi.org/10.1074/jbc.M112.375881

@article{ee5e80fe473a4ac88e106c4cfcdfeaf6,

title = "Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis",

abstract = "Background: Factors that regulate intestinal stem cell (ISC) proliferation and apoptosis are unknown. Results: Toll-like receptor 4 (TLR4) is expressed on ISCs and regulates their proliferation and apoptosis, which is critical in the pathogenesis of necrotizing enterocolitis (NEC). Conclusion: TLR4 regulates ISC proliferation and apoptosis. Significance: This is the first study showing that ISC regulation by microbial receptors contributes to NEC pathogenesis.",

author = "Neal, \{Matthew D.\} and Sodhi, \{Chhinder P.\} and Hongpeng Jia and Mitchell Dyer and Egan, \{Charlotte E.\} and Ibrahim Yazji and Misty Good and Amin Afrazi and Ryan Marino and Dennis Slagle and Congrong Ma and Branca, \{Maria F.\} and Thomas Prindle and Zachary Grant and John Ozolek and Hackam, \{David J.\}",

year = "2012",

month = oct,

day = "26",

doi = "10.1074/jbc.M112.375881",

language = "English (US)",

volume = "287",

pages = "37296--37308",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology Inc.",

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TY - JOUR

T1 - Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis

AU - Neal, Matthew D.

AU - Sodhi, Chhinder P.

AU - Jia, Hongpeng

AU - Dyer, Mitchell

AU - Egan, Charlotte E.

AU - Yazji, Ibrahim

AU - Good, Misty

AU - Afrazi, Amin

AU - Marino, Ryan

AU - Slagle, Dennis

AU - Ma, Congrong

AU - Branca, Maria F.

AU - Prindle, Thomas

AU - Grant, Zachary

AU - Ozolek, John

AU - Hackam, David J.

PY - 2012/10/26

Y1 - 2012/10/26

N2 - Background: Factors that regulate intestinal stem cell (ISC) proliferation and apoptosis are unknown. Results: Toll-like receptor 4 (TLR4) is expressed on ISCs and regulates their proliferation and apoptosis, which is critical in the pathogenesis of necrotizing enterocolitis (NEC). Conclusion: TLR4 regulates ISC proliferation and apoptosis. Significance: This is the first study showing that ISC regulation by microbial receptors contributes to NEC pathogenesis.

AB - Background: Factors that regulate intestinal stem cell (ISC) proliferation and apoptosis are unknown. Results: Toll-like receptor 4 (TLR4) is expressed on ISCs and regulates their proliferation and apoptosis, which is critical in the pathogenesis of necrotizing enterocolitis (NEC). Conclusion: TLR4 regulates ISC proliferation and apoptosis. Significance: This is the first study showing that ISC regulation by microbial receptors contributes to NEC pathogenesis.

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U2 - 10.1074/jbc.M112.375881

DO - 10.1074/jbc.M112.375881

M3 - Article

C2 - 22955282

AN - SCOPUS:84868261605

SN - 0021-9258

VL - 287

SP - 37296

EP - 37308

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 44

ER -

Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis

Abstract

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