Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis

Matthew D. Neal; Chhinder P. Sodhi; Hongpeng Jia; Mitchell Dyer; Charlotte E. Egan; Ibrahim Yazji; Misty Good; Amin Afrazi; Ryan Marino; Dennis Slagle; Congrong Ma; Maria F. Branca; Thomas Prindle; Zachary Grant; John Ozolek; David J. Hackam

doi:10.1074/jbc.M112.375881

Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis

Matthew D. Neal, Chhinder P. Sodhi, Hongpeng Jia, Mitchell Dyer, Charlotte E. Egan, Ibrahim Yazji, Misty Good, Amin Afrazi, Ryan Marino, Dennis Slagle, Congrong Ma, Maria F. Branca, Thomas Prindle, Zachary Grant, John Ozolek, David J. Hackam

Research output: Contribution to journal › Article › peer-review

114 Scopus citations

Abstract

Background: Factors that regulate intestinal stem cell (ISC) proliferation and apoptosis are unknown. Results: Toll-like receptor 4 (TLR4) is expressed on ISCs and regulates their proliferation and apoptosis, which is critical in the pathogenesis of necrotizing enterocolitis (NEC). Conclusion: TLR4 regulates ISC proliferation and apoptosis. Significance: This is the first study showing that ISC regulation by microbial receptors contributes to NEC pathogenesis.

Original language	English (US)
Pages (from-to)	37296-37308
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	287
Issue number	44
DOIs	https://doi.org/10.1074/jbc.M112.375881
State	Published - Oct 26 2012
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Neal, M. D., Sodhi, C. P., Jia, H., Dyer, M., Egan, C. E., Yazji, I., Good, M., Afrazi, A., Marino, R., Slagle, D., Ma, C., Branca, M. F., Prindle, T., Grant, Z., Ozolek, J., & Hackam, D. J. (2012). Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis. Journal of Biological Chemistry, 287(44), 37296-37308. https://doi.org/10.1074/jbc.M112.375881

Neal, MD, Sodhi, CP , Jia, H, Dyer, M, Egan, CE, Yazji, I, Good, M, Afrazi, A, Marino, R, Slagle, D, Ma, C, Branca, MF, Prindle, T, Grant, Z, Ozolek, J & Hackam, DJ 2012, 'Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis', Journal of Biological Chemistry, vol. 287, no. 44, pp. 37296-37308. https://doi.org/10.1074/jbc.M112.375881

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title = "Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis",

abstract = "Background: Factors that regulate intestinal stem cell (ISC) proliferation and apoptosis are unknown. Results: Toll-like receptor 4 (TLR4) is expressed on ISCs and regulates their proliferation and apoptosis, which is critical in the pathogenesis of necrotizing enterocolitis (NEC). Conclusion: TLR4 regulates ISC proliferation and apoptosis. Significance: This is the first study showing that ISC regulation by microbial receptors contributes to NEC pathogenesis.",

author = "Neal, {Matthew D.} and Sodhi, {Chhinder P.} and Hongpeng Jia and Mitchell Dyer and Egan, {Charlotte E.} and Ibrahim Yazji and Misty Good and Amin Afrazi and Ryan Marino and Dennis Slagle and Congrong Ma and Branca, {Maria F.} and Thomas Prindle and Zachary Grant and John Ozolek and Hackam, {David J.}",

year = "2012",

month = oct,

day = "26",

doi = "10.1074/jbc.M112.375881",

language = "English (US)",

volume = "287",

pages = "37296--37308",

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TY - JOUR

T1 - Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis

AU - Neal, Matthew D.

AU - Sodhi, Chhinder P.

AU - Jia, Hongpeng

AU - Dyer, Mitchell

AU - Egan, Charlotte E.

AU - Yazji, Ibrahim

AU - Good, Misty

AU - Afrazi, Amin

AU - Marino, Ryan

AU - Slagle, Dennis

AU - Ma, Congrong

AU - Branca, Maria F.

AU - Prindle, Thomas

AU - Grant, Zachary

AU - Ozolek, John

AU - Hackam, David J.

PY - 2012/10/26

Y1 - 2012/10/26

N2 - Background: Factors that regulate intestinal stem cell (ISC) proliferation and apoptosis are unknown. Results: Toll-like receptor 4 (TLR4) is expressed on ISCs and regulates their proliferation and apoptosis, which is critical in the pathogenesis of necrotizing enterocolitis (NEC). Conclusion: TLR4 regulates ISC proliferation and apoptosis. Significance: This is the first study showing that ISC regulation by microbial receptors contributes to NEC pathogenesis.

AB - Background: Factors that regulate intestinal stem cell (ISC) proliferation and apoptosis are unknown. Results: Toll-like receptor 4 (TLR4) is expressed on ISCs and regulates their proliferation and apoptosis, which is critical in the pathogenesis of necrotizing enterocolitis (NEC). Conclusion: TLR4 regulates ISC proliferation and apoptosis. Significance: This is the first study showing that ISC regulation by microbial receptors contributes to NEC pathogenesis.

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Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis

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