Tolerance of preschoolers to two dosage strengths of vitamin A preparation

R. F. Florentino, C. C. Tanchoco, A. C. Ramos, T. S. Mendoza, E. P. Natividad, J. B.M. Tangco, A. Sommer

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


The tolerance to two alternative large-dosage strengths of vitamin A preparation was determined in a double-blind study involving 2471 children in two municipalities in the Philippines. Each child, aged 1-6 y, not suffering from active xerophthalmia or from nausea and/or vomiting, headache, diarrhea, and fever, was randomly given 1 mL of a syrupy suspension later identified to contain 0, 60, or 30 mg vitamin A. Clinical evaluation of subjects was done by physicians 24 h and 1 wk after dosing. Nausea and/or vomiting and headache were twice as common among children given 60 mg than those given 30 mg. Severe vomiting (1.2%) was confined to those given 60 mg. Almost all experienced their symptoms within 24 h after dosing; symptoms lasted for no more than 12-24 h. The incidence of diarrhea and fever for vitamin A recipients was not significantly different from that of those receiving placebo.

Original languageEnglish (US)
Pages (from-to)694-700
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Issue number4
StatePublished - 1990


  • High dose
  • Side effects
  • Supplement
  • Toxicity
  • Trial
  • Vitamin A

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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