@article{eacbdbb2cbf14ee0b264a6df29a8ad68,
title = "Tobacco smoking and binge alcohol use are associated with incident venous thromboembolism in an HIV cohort",
abstract = "Background: People with HIV (PWH) are at increased risk of cardiovascular comorbidities and substance use is a potential predisposing factor. We evaluated associations of tobacco smoking and alcohol use with venous thromboembolism (VTE) in PWH. Methods: We assessed incident, centrally adjudicated VTE among 12 957 PWH within the Centers for AIDS Research Network of Integrated Clinical Systems (CNICS) cohort between January 2009 and December 2018. Using separate Cox proportional hazards models, we evaluated associations of time-updated alcohol and cigarette use with VTE, adjusting for demographic and clinical characteristics. Smoking was evaluated as pack-years and never, former, or current use with current cigarettes per day. Alcohol use was parameterized using categorical and continuous alcohol use score, frequency of use, and binge frequency. Results: During a median of 3.6 years of follow-up, 213 PWH developed a VTE. One-third of PWH reported binge drinking and 40% reported currently smoking. In adjusted analyses, risk of VTE was increased among both current (HR: 1.44, 95% CI: 1.02–2.03) and former (HR: 1.44, 95% CI: 0.99–2.07) smokers compared to PWH who never smoked. Additionally, total pack-years among ever-smokers (HR: 1.10 per 5 pack-years; 95% CI: 1.03–1.18) was associated with incident VTE in a dose-dependent manner. Frequency of binge drinking was associated with incident VTE (HR: 1.30 per 7 days/month, 95% CI: 1.11–1.52); however, alcohol use frequency was not. Severity of alcohol use was not significantly associated with VTE. Conclusions: Current smoking and pack-year smoking history were dose-dependently associated with incident VTE among PWH in CNICS. Binge drinking was also associated with VTE. Interventions for smoking and binge drinking may decrease VTE risk among PWH.",
keywords = "HIV, binge drinking, smoking, substance use, venous thromboembolism",
author = "Brandon Luu and Stephanie Ruderman and Robin Nance and Delaney, {Joseph A.C.} and Jimmy Ma and Andrew Hahn and Heckbert, {Susan R.} and Budoff, {Matthew J.} and Kristina Crothers and Mathews, {William C.} and Katerina Christopolous and Hunt, {Peter W.} and Joseph Eron and Richard Moore and Jeanne Keruly and Lober, {William B.} and Burkholder, {Greer A.} and Amanda Willig and Geetanjali Chander and McCaul, {Mary E.} and Karen Cropsey and Conall O'Cleirigh and Inga Peter and Matthew Feinstein and Tsui, {Judith I.} and Sara Lindstroem and Michael Saag and Kitahata, {Mari M.} and Crane, {Heidi M.} and Drumright, {Lydia N.} and Whitney, {Bridget M.}",
note = "Funding Information: HMC and WBL have received grant funding from ViiV Healthcare. The other authors report no potential conflicts of interest, including relevant financial interests, activities, relationships, and affiliations. Funding Information: This work was supported by the National Heart, Lung, and Blood Institute (NHLBI) at the National Institutes of Health (R01 HL126538). Additional support came from the National Institutes of Alcohol Abuse and Alcoholism (NIAAA) (U24AA020801, U01AA020793, and U01AA020802), the National Institute of Allergy and Infectious Diseases (NIAID) (CNICS R24 AI067039, UW CFAR NIAID Grant P30 AI027757; UAB CFAR grant P30 AI027767; UNC CFAR grant P30 AI50410; and JHU CFAR grant P30 AI094189), and the National Institute on Drug Abuse (NIDA) (R01DA047045, RO1DA044112, and U01DA036935). The authors would like to acknowledge all CNICS study participants and personnel for their contributions to this work. Funding Information: This work was supported by the National Heart, Lung, and Blood Institute (NHLBI) at the National Institutes of Health (R01 HL126538). Additional support came from the National Institutes of Alcohol Abuse and Alcoholism (NIAAA) (U24AA020801, U01AA020793, and U01AA020802), the National Institute of Allergy and Infectious Diseases (NIAID) (CNICS R24 AI067039, UW CFAR NIAID Grant P30 AI027757; UAB CFAR grant P30 AI027767; UNC CFAR grant P30 AI50410; and JHU CFAR grant P30 AI094189), and the National Institute on Drug Abuse (NIDA) (R01DA047045, RO1DA044112, and U01DA036935). Publisher Copyright: {\textcopyright} 2022 British HIV Association.",
year = "2022",
month = nov,
doi = "10.1111/hiv.13309",
language = "English (US)",
volume = "23",
pages = "1051--1060",
journal = "HIV Medicine",
issn = "1464-2662",
publisher = "Wiley-Blackwell",
number = "10",
}