TY - JOUR
T1 - Tobacco craving in smokers with and without schizophrenia
AU - Lo, Suzanne
AU - Heishman, Stephen J.
AU - Raley, Heather
AU - Wright, Katherine
AU - Wehring, Heidi J.
AU - Moolchan, Eric T.
AU - Feldman, Stephanie
AU - Liu, Fang
AU - McMahon, Robert P.
AU - Richardson, Charles M.
AU - Kelly, Deanna L.
PY - 2011/4
Y1 - 2011/4
N2 - We examined tobacco craving and dependence in current smokers (18-65 years) with schizophrenia (N= 100) and those without a psychiatric disorder (normal controls, N= 100). During the 2-3 h visit participants completed demographic and smoking-related questionnaires and provided a breath CO sample. The Tobacco Craving Questionnaire-Short Form (TCQ-SF) was administered. Immediately after smoking one cigarette, no difference in TCQ-SF total score was noted (46.7 ± 19.5 schizophrenia, 42.8 ± 18.2 controls, p= 0.15); however, after 15 min TCQ-SF total score was significantly higher in people with schizophrenia (50.0 ± 19.6) than in controls (38.6 ± 19.4) (p= 0.0014). TCQ-SF factors of emotionality (p= 0.0015), compulsivity (p= 0.0003) and purposefulness (p= 0.0174) were significantly greater in the schizophrenia group than the control group. FTND scores (5.5 ± 2.0 vs 5.3 ± 2.0, p= 0.62) number of cigarettes smoked daily (17.9 ± 11.6 vs. 17.0 ± 7.9), expired breath CO (28.0 ± 14.5. ppm vs. 22.0 ± 8.0. ppm) and age at smoking initiation (16.2 ± 5.4 vs. 15.6 ± 5.5. years, p= 0.44) did not differ in the schizophrenia and control groups respectively. In conclusion, tobacco craving as measured by the TCQ-SF was significantly greater in people with schizophrenia than controls 15 min post-smoking, despite similar scores in dependence and similar smoking histories and current smoking patterns.
AB - We examined tobacco craving and dependence in current smokers (18-65 years) with schizophrenia (N= 100) and those without a psychiatric disorder (normal controls, N= 100). During the 2-3 h visit participants completed demographic and smoking-related questionnaires and provided a breath CO sample. The Tobacco Craving Questionnaire-Short Form (TCQ-SF) was administered. Immediately after smoking one cigarette, no difference in TCQ-SF total score was noted (46.7 ± 19.5 schizophrenia, 42.8 ± 18.2 controls, p= 0.15); however, after 15 min TCQ-SF total score was significantly higher in people with schizophrenia (50.0 ± 19.6) than in controls (38.6 ± 19.4) (p= 0.0014). TCQ-SF factors of emotionality (p= 0.0015), compulsivity (p= 0.0003) and purposefulness (p= 0.0174) were significantly greater in the schizophrenia group than the control group. FTND scores (5.5 ± 2.0 vs 5.3 ± 2.0, p= 0.62) number of cigarettes smoked daily (17.9 ± 11.6 vs. 17.0 ± 7.9), expired breath CO (28.0 ± 14.5. ppm vs. 22.0 ± 8.0. ppm) and age at smoking initiation (16.2 ± 5.4 vs. 15.6 ± 5.5. years, p= 0.44) did not differ in the schizophrenia and control groups respectively. In conclusion, tobacco craving as measured by the TCQ-SF was significantly greater in people with schizophrenia than controls 15 min post-smoking, despite similar scores in dependence and similar smoking histories and current smoking patterns.
KW - Craving
KW - Dependency
KW - Nicotine
KW - Schizophrenia
KW - Smoking
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U2 - 10.1016/j.schres.2010.06.017
DO - 10.1016/j.schres.2010.06.017
M3 - Article
C2 - 20637571
AN - SCOPUS:79952317475
SN - 0920-9964
VL - 127
SP - 241
EP - 245
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 1-3
ER -