Tobacco-alcohol amblyopia: A proposed biochemical basis for pathogenesis

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Tobacco-alcohol or nutritional amblyopia is a rare disorder of decreased central vision associated with nutritional deficiencies and tobacco smoking. Although folate deficiency is common in patients with tobacco-alcohol amblyopia, the role of folic acid in this disorder has been underplayed. The role of cyanide from tobacco smoke, folate and other dietary deficiencies will be reviewed. A new model of the pathogenesis of tobacco-alcohol amblyopia is proposed based on the presumptive alteration of methionine and S-adenosyl-L-methionine metabolism.

Original languageEnglish (US)
Pages (from-to)1317-1328
Number of pages12
JournalMedical Hypotheses
Issue number11
StatePublished - 1981

ASJC Scopus subject areas

  • Developmental Biology
  • Medicine(all)
  • Drug Discovery


Dive into the research topics of 'Tobacco-alcohol amblyopia: A proposed biochemical basis for pathogenesis'. Together they form a unique fingerprint.

Cite this