To evaluate the damage of renal function in CIAKI rats at 3T: Using ASL and BOLD MRI

Wen Bo Chen, Long Liang, Bin Zhang, Chun Ling Liu, Hong Jun Liu, Hai Ying Luo, Qiong Xin Zeng, Chang Hong Liang, Guan Shu Liu, Shui Xing Zhang

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Purpose. To investigate noninvasive arterial spin-labeling (ASL) and blood oxygen level-dependent imaging (BOLD) sequences for measuring renal hemodynamics and oxygenation in contrast induced acute kidney injury (CIAKI) rat. Materials and Methods. Thirteen SD rats were randomly grouped into CIAKI group and control group. Both ASL and BOLD sequences were performed at 24 h preinjection and at intervals of 0.5, 12, 24, 48, 72, and 96 h postinjection to assess renal blood flow (RBF) and relative spin-spin relaxation rate (R 2), respectively. Results. For the CIAKI group, the value of RBF in the cortex (CO) and outer medulla (OM) of the kidney was significantly decreased (P < 0.05) at 12-48 h and regressed to baseline level (P = NS) at 72-96 h. In OM, the value of R 2 was increased at 0.5-48 h (P < 0.05) and not statistically significant (P = NS) at 72 and 96 h. Conclusions. RBF in OM and CO and oxygen level in OM were decreased postinjection of CM. ASL combining BOLD can further identify the primary cause of the decrease of renal oxygenation in CIAKI. This approach provides means for noninvasive monitoring renal function during the first 4 days of CIAKI in clinical routine work.

Original languageEnglish (US)
Article number593060
JournalBioMed research international
StatePublished - 2015

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Immunology and Microbiology


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