TY - JOUR
T1 - Titin, a huge, elastic sarcomeric protein with a probable role in morphogenesis
AU - Fulton, Alice B.
AU - Isaacs, William B.
PY - 1991/4
Y1 - 1991/4
N2 - Titin, the largest protein identified to date (over 1 μm long, almost 3 million daltons in mass) is the third most abundant component of the sarcomere. In the mature myofibril, titin molecules span from M line to Z line, forming a third filament system which provides sarcomeric alignment and elastic recoil. In the developing sarcomere, accumulating evidence from studies both in vivo and in vitro implicates titin as part of a morphogenetic scaffolding, upon which critical events in myofibrillogenesis are coordinated in a time‐ and spacedependent manner.
AB - Titin, the largest protein identified to date (over 1 μm long, almost 3 million daltons in mass) is the third most abundant component of the sarcomere. In the mature myofibril, titin molecules span from M line to Z line, forming a third filament system which provides sarcomeric alignment and elastic recoil. In the developing sarcomere, accumulating evidence from studies both in vivo and in vitro implicates titin as part of a morphogenetic scaffolding, upon which critical events in myofibrillogenesis are coordinated in a time‐ and spacedependent manner.
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U2 - 10.1002/bies.950130403
DO - 10.1002/bies.950130403
M3 - Review article
C2 - 1859393
AN - SCOPUS:0026147304
SN - 0265-9247
VL - 13
SP - 157
EP - 161
JO - BioEssays
JF - BioEssays
IS - 4
ER -