Tissue-resident natural killer (NK) cells are cell lineages distinct from thymic and conventional splenic NK cells

Dorothy K. Sojka, Beatrice Plougastel-Douglas, Liping Yang, Melissa A. Pak-Wittel, Maxim N. Artyomov, Yulia Ivanova, Chao Zhong, Julie M. Chase, Paul B. Rothman, Jenny Yu, Joan K. Riley, Jinfang Zhu, Zhigang Tian, Wayne M. Yokoyama

Research output: Contribution to journalArticlepeer-review

308 Scopus citations


Natural killer (NK) cells belong to the innate immune system; they can control virus infections and developing tumors by cytotoxicity and producing inflammatory cytokines. Most studies of mouse NK cells, however, have focused on conventional NK (cNK) cells in the spleen. Recently, we described two populations of liver NK cells, tissue-resident NK (trNK) cells and those resembling splenic cNK cells. However, their lineage relationship was unclear; trNK cells could be developing cNK cells, related to thymic NK cells, or a lineage distinct from both cNK and thymic NK cells. Herein we used detailed transcriptomic, flow cytometric, and functional analysis and transcription factor-deficient mice to determine that liver trNK cells form a distinct lineage from cNK and thymic NK cells. Taken together with analysis of trNK cells in other tissues, there are at least four distinct lineages of NK cells: cNK, thymic, liver (and skin) trNK, and uterine trNK cells.

Original languageEnglish (US)
Article numbere01659
Issue number3
StatePublished - Apr 8 2014

ASJC Scopus subject areas

  • General Neuroscience
  • General Immunology and Microbiology
  • General Biochemistry, Genetics and Molecular Biology


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