TY - GEN
T1 - Tiny-TOF-MALDI mass spectrometry for particulate drug and explosives detection
AU - Bryden, Wayne A.
AU - Benson, Richard C.
AU - Ecelberger, Scott A.
AU - Phillips, Terry E.
AU - Cornish, Timothy
AU - Cotter, Robert J.
PY - 1995/12/1
Y1 - 1995/12/1
N2 - The MALDI (matrix assisted laser desorption/ionization) technique, widely used to desorb and ionize large biomolecules, is applied here to small molecules having low vapor pressure, such as drugs and explosives. Furthermore, we report the coupling of the MALDI technique with a small, highly portable tiny-TOF (time-of-flight) mass spectrometer developed in our laboratories. This mass spectrometer is a low voltage coaxial reflectron design with a short flight tube that is specifically designed for low molecular weight substances. The reflectron is designed to operate in two different modes that provide an extremely powerful pseudo-tandem mass spectrometry capability that is crucial for field applications. Using this system we have measured mass spectral signatures for cocaine, heroine, and the explosive RDX in the sub-nanogram range. Also reported here are continued developments on advanced MALDI sampling technologies, sensitivity, and mass resolution enhancements of the tiny-TOF, further decreases in system size and weight, and concepts for field operational systems.
AB - The MALDI (matrix assisted laser desorption/ionization) technique, widely used to desorb and ionize large biomolecules, is applied here to small molecules having low vapor pressure, such as drugs and explosives. Furthermore, we report the coupling of the MALDI technique with a small, highly portable tiny-TOF (time-of-flight) mass spectrometer developed in our laboratories. This mass spectrometer is a low voltage coaxial reflectron design with a short flight tube that is specifically designed for low molecular weight substances. The reflectron is designed to operate in two different modes that provide an extremely powerful pseudo-tandem mass spectrometry capability that is crucial for field applications. Using this system we have measured mass spectral signatures for cocaine, heroine, and the explosive RDX in the sub-nanogram range. Also reported here are continued developments on advanced MALDI sampling technologies, sensitivity, and mass resolution enhancements of the tiny-TOF, further decreases in system size and weight, and concepts for field operational systems.
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M3 - Conference contribution
AN - SCOPUS:0029492277
SN - 0819418692
SN - 9780819418692
T3 - Proceedings of SPIE - The International Society for Optical Engineering
SP - 153
EP - 164
BT - Proceedings of SPIE - The International Society for Optical Engineering
T2 - Law Enforcement Technologies: Identification Technologies and Traffic Safety
Y2 - 21 June 1995 through 22 June 1995
ER -