TY - GEN
T1 - Time-varying lung ventilation analysis of 4DCT using image registration
AU - Ding, Kai
AU - Du, Kaifang
AU - Cao, Kunlin
AU - Christensen, Gary E.
AU - Reinhardt, Joseph M.
PY - 2011
Y1 - 2011
N2 - Imaging techniques for measuring lung ventilation are essential tools to study lung tissue response to radiation therapy. Most of the existing CT and image registration based ventilation measurement methods use two extreme phases (end expiration and end inspiration) while ignoring the important ventilation variation within the respiratory cycle. In this paper, we present a new instantaneous ventilation measurement scheme using multiple 4DCT phase images and regularized 3D image registration, which aims at measuring the regional ventilation within the respiratory cycle. The ventilation is measured using the Jacobian (a function of local partial derivatives) of the registration displacement field. For all four animals, 39% of the total lung volume reaches maximum ventilation at T2 (50% inspiration phase) during inspiration and the 75% of the total lung volume reaches maximum ventilation at T 5 (75% expiration phase) during expiration. The registration accuracy assessed by 200 semi-automatically matched landmarks in all phases and animals show landmark error on the order of 1 mm after registration.
AB - Imaging techniques for measuring lung ventilation are essential tools to study lung tissue response to radiation therapy. Most of the existing CT and image registration based ventilation measurement methods use two extreme phases (end expiration and end inspiration) while ignoring the important ventilation variation within the respiratory cycle. In this paper, we present a new instantaneous ventilation measurement scheme using multiple 4DCT phase images and regularized 3D image registration, which aims at measuring the regional ventilation within the respiratory cycle. The ventilation is measured using the Jacobian (a function of local partial derivatives) of the registration displacement field. For all four animals, 39% of the total lung volume reaches maximum ventilation at T2 (50% inspiration phase) during inspiration and the 75% of the total lung volume reaches maximum ventilation at T 5 (75% expiration phase) during expiration. The registration accuracy assessed by 200 semi-automatically matched landmarks in all phases and animals show landmark error on the order of 1 mm after registration.
KW - image registration
KW - pulmonary
KW - radiation therapy
KW - ventilation
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U2 - 10.1109/ICASSP.2011.5947672
DO - 10.1109/ICASSP.2011.5947672
M3 - Conference contribution
AN - SCOPUS:80051631211
SN - 9781457705397
T3 - ICASSP, IEEE International Conference on Acoustics, Speech and Signal Processing - Proceedings
SP - 5772
EP - 5775
BT - 2011 IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP 2011 - Proceedings
T2 - 36th IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP 2011
Y2 - 22 May 2011 through 27 May 2011
ER -