Time to disease recurrence in noninfectious uveitis following long-acting injectable fluocinolone acetonide implant

Cindy X. Cai, Cindy Skalak, Robert T. Keenan, Dilraj S. Grewal, Glenn J. Jaffe

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Purpose: To determine the time to disease recurrence with long-acting injectable fluocinolone acetonide implant (FAi) for noninfectious intermediate, posterior, and panuveitis. Methods: This was a retrospective study of patients with at least 12 months of follow-up who had completed a 2-year prospective, investigational new drug study with 0.18-mg FAi. Time to uveitis recurrence or cystoid macular edema (CME) occurrence was recorded. Results: Twelve eyes from 12 participants (mean age 43 years, range 25–64 years) were included. Patients were followed for a mean of 34.2 months (range, 12.0–56.9 months) after completion of the prospective trial. Five eyes (42%) did not have a documented uveitis recurrence or CME occurrence. Five eyes (42%) had a uveitis recurrence with the mean time to recurrence 36.1 months (range, 22.8–61.1 months) after FAi implantation. Two eyes (16%) had CME alone, the mean time to occurrence 36.9 months (range 36.1–42.1 months). On Kaplan-Meier analysis, the estimated probability of remaining recurrence-free 36 months after FAi implantation was 0.67 (95% confidence interval, 0.34–0.86). Conclusions: Data of study participants after completing a clinical trial suggest that the injectable FAi for noninfectious uveitis can provide control for 3 years on average. These long-term data support the use of FAi to control noninfectious uveitis.

Original languageEnglish (US)
Pages (from-to)1023-1030
Number of pages8
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Issue number5
StatePublished - May 1 2020
Externally publishedYes


  • Injectable fluocinolone
  • Intraocular steroid
  • Noninfectious uveitis
  • Retina

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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