TY - JOUR
T1 - Time-Series Analysis of Meningococcal Disease in Catalonia
AU - Domínguez, Angela
AU - Muñoz, Pilar
AU - Cardeñosa, Neus
AU - Martínez, Ana
AU - Caylà, Joan
N1 - Funding Information:
This work was partially supported by the Fondo de Investigaciones Sanitarias, Instituto de Salud Carlos III (Red de Centros de Investigación en Epidemiología y Salud Pública, RCESP and CIBER on Epidemiology and Public Health).
PY - 2007/9
Y1 - 2007/9
N2 - Purpose: In Catalonia, a region in the northeast of Spain, a rate of five cases of meningococcal disease per 100,000 inhabitants was reported during the period of 1996-1997, which was higher than in previous years. The objective of this study was to analyze the temporal behavior of serogroup B and C meningococcal disease cases in Catalonia. Methods: The study included confirmed cases of meningococcal disease from the 4-week period 11 of 1996 to the 4-week period 10 of 2004. A Poisson regression model (GLM) was fit for time series of serogroup B cases, whereas a zero-inflated Poisson model (ZIP) was necessary to adjust time series of serogroup C cases. Results: The evolution of cases in both serogroups was correlated over time. For serogroup B, there was also an association with the influenza epidemics reported in four of the seasons analyzed. For serogroup C, a positive association with three influenza epidemics and a negative association with vaccination campaigns were found. Time series analysis of meningococcal disease shows that serogroups B and C behave in a different way. Conclusions: The study of the evolution of each serogroup may be useful in evaluating vaccination strategies.
AB - Purpose: In Catalonia, a region in the northeast of Spain, a rate of five cases of meningococcal disease per 100,000 inhabitants was reported during the period of 1996-1997, which was higher than in previous years. The objective of this study was to analyze the temporal behavior of serogroup B and C meningococcal disease cases in Catalonia. Methods: The study included confirmed cases of meningococcal disease from the 4-week period 11 of 1996 to the 4-week period 10 of 2004. A Poisson regression model (GLM) was fit for time series of serogroup B cases, whereas a zero-inflated Poisson model (ZIP) was necessary to adjust time series of serogroup C cases. Results: The evolution of cases in both serogroups was correlated over time. For serogroup B, there was also an association with the influenza epidemics reported in four of the seasons analyzed. For serogroup C, a positive association with three influenza epidemics and a negative association with vaccination campaigns were found. Time series analysis of meningococcal disease shows that serogroups B and C behave in a different way. Conclusions: The study of the evolution of each serogroup may be useful in evaluating vaccination strategies.
KW - Meningococcal disease
KW - Serogroup B, Serogroup C
KW - Time-series analysis
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U2 - 10.1016/j.annepidem.2007.03.006
DO - 10.1016/j.annepidem.2007.03.006
M3 - Article
C2 - 17555986
AN - SCOPUS:34548047246
SN - 1047-2797
VL - 17
SP - 654
EP - 662
JO - Annals of epidemiology
JF - Annals of epidemiology
IS - 9
ER -