Time-dependent effects of a haloperidol challenge on energy metabolism in the normal human brain

Elsa J. Bartlett; Jonathan D. Brodie; Philip Simkowitz; Stephen L. Dewey; Henry Rusinek; Nora D. Volkow; Alfred P. Wolf; Gwenn Smith; Adam Wolkin; Robert Cancro

doi:10.1016/0165-1781(96)02711-4

Time-dependent effects of a haloperidol challenge on energy metabolism in the normal human brain

Elsa J. Bartlett, Jonathan D. Brodie, Philip Simkowitz, Stephen L. Dewey, Henry Rusinek, Nora D. Volkow, Alfred P. Wolf, Gwenn Smith, Adam Wolkin, Robert Cancro

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Positron emission tomography and the fluorodeoxyglucose method were used to measure regional brain metabolism before and 2 h after haloperidol (5 mg, i.m.) in 11 young normal men. These data were compared with measures obtained from nine previously studied normal men who had received no drug intervention. Although a previously published study had demonstrated significantly decreased metabolism in whole brain, neocortex, limbic cortex, thalamus, and caudate nucleus 12 h after a 5-mg dose of haloperidol, the present 2-h study did not show significant metabolic changes despite the fact that significant extrapyramidal effects occurred. Taken together, these studies demonstrate differences in the temporal organization of behavioral and metabolic responses to haloperidol challenge.

Original language	English (US)
Pages (from-to)	91-99
Number of pages	9
Journal	Psychiatry research
Volume	60
Issue number	2-3
DOIs	https://doi.org/10.1016/0165-1781(96)02711-4
State	Published - Mar 29 1996
Externally published	Yes

Keywords

Cerebral metabolism
Dopamine receptors
Neuroleptics
Positron emission tomography
Schizophrenia

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/0165-1781(96)02711-4

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title = "Time-dependent effects of a haloperidol challenge on energy metabolism in the normal human brain",

abstract = "Positron emission tomography and the fluorodeoxyglucose method were used to measure regional brain metabolism before and 2 h after haloperidol (5 mg, i.m.) in 11 young normal men. These data were compared with measures obtained from nine previously studied normal men who had received no drug intervention. Although a previously published study had demonstrated significantly decreased metabolism in whole brain, neocortex, limbic cortex, thalamus, and caudate nucleus 12 h after a 5-mg dose of haloperidol, the present 2-h study did not show significant metabolic changes despite the fact that significant extrapyramidal effects occurred. Taken together, these studies demonstrate differences in the temporal organization of behavioral and metabolic responses to haloperidol challenge.",

keywords = "Cerebral metabolism, Dopamine receptors, Neuroleptics, Positron emission tomography, Schizophrenia",

author = "Bartlett, {Elsa J.} and Brodie, {Jonathan D.} and Philip Simkowitz and Dewey, {Stephen L.} and Henry Rusinek and Volkow, {Nora D.} and Wolf, {Alfred P.} and Gwenn Smith and Adam Wolkin and Robert Cancro",

note = "Funding Information: This research was supported by grants MH-47277, RR-00096, and NS-15638 from the National Institutes of Health by a NARSAD established Investigator Award to J.D. Brodie and by contract DE-AC02-76CH00016, the U.S. Department of Energy and its Office of Health and Environmental Research, to Brookhaven National Laboratory. The authors thank Arlene Hurley and the nursing staff at the New York University Clinical Research Center. Gratitude is also owed to Eugene Laska, Morri's Meissner, Thomas Cooper, Faouzia Barouche, Wai Hon Tsui, Berekti Twelde, David Schlyer, Joanna S. Fowler, Carol Redvanly, Colleen Shea, David Alexoff, Payton King, Donald Warner, Naomi Pappas, Noeiwah Netusil, Theodore Johnson, and Harry Ulyat for advice and assistance.",

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AU - Bartlett, Elsa J.

AU - Brodie, Jonathan D.

AU - Simkowitz, Philip

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AU - Rusinek, Henry

AU - Volkow, Nora D.

AU - Wolf, Alfred P.

AU - Smith, Gwenn

AU - Wolkin, Adam

AU - Cancro, Robert

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N2 - Positron emission tomography and the fluorodeoxyglucose method were used to measure regional brain metabolism before and 2 h after haloperidol (5 mg, i.m.) in 11 young normal men. These data were compared with measures obtained from nine previously studied normal men who had received no drug intervention. Although a previously published study had demonstrated significantly decreased metabolism in whole brain, neocortex, limbic cortex, thalamus, and caudate nucleus 12 h after a 5-mg dose of haloperidol, the present 2-h study did not show significant metabolic changes despite the fact that significant extrapyramidal effects occurred. Taken together, these studies demonstrate differences in the temporal organization of behavioral and metabolic responses to haloperidol challenge.

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Time-dependent effects of a haloperidol challenge on energy metabolism in the normal human brain

Abstract

Keywords

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