TigrScan and GlimmerHMM: Two open source ab initio eukaryotic gene-finders

W. H. Majoros, M. Pertea, S. L. Salzberg

Research output: Contribution to journalArticlepeer-review

551 Scopus citations


Summary: We describe two new Generalized Hidden Markov Model implementations for ab initio eukaryotic gene prediction. The C/C++ source code for both is available as open source and is highly reusable due to their modular and extensible architectures. Unlike most of the currently available gene-finders, the programs are re-trainable by the end user. They are also re-configurable and include several types of probabilistic submodels which can be independently combined, such as Maximal Dependence Decomposition trees and interpolated Markov models. Both programs have been used at TIGR for the annotation of the Aspergillus fumigatus and Toxoplasma gondii genomes.

Original languageEnglish (US)
Pages (from-to)2878-2879
Number of pages2
Issue number16
StatePublished - Nov 1 2004
Externally publishedYes

ASJC Scopus subject areas

  • Statistics and Probability
  • Biochemistry
  • Molecular Biology
  • Computer Science Applications
  • Computational Theory and Mathematics
  • Computational Mathematics


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