Abstract
Several observations suggest a relationship between thyroid hormone and the endogenous opiates, enkephalins and endorphin. Morphine (Shahid-Salles and Donovan 1977) and leucine-enkephalin (May, Mittler, Manougian and Ertel 1979) blunt TSH response to TRH in vivo. TRH overcomes the CNS depressant effects of beta-endorphin (Collu, Tache and Lis 1977). In addition, thyroid hormone can modify CNS levels of beta-endorphin (Panerai, Lee and Bellabarba 1979). Since CNS beta-endorphin and ACTH are derived from a common precursor (Mains, Eipper and Ling 1977), we studied the role of thyroid hormone in the regulation of both of these peptides.
Original language | English (US) |
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Pages (from-to) | 345-346 |
Number of pages | 2 |
Journal | Hormone and Metabolic Research |
Volume | 12 |
Issue number | 7 |
DOIs | |
State | Published - Jan 1 1980 |
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Biochemistry
- Endocrinology
- Clinical Biochemistry
- Biochemistry, medical