Thymus dependent (T) lymphocytes in the rat may be recognized by their reactions with fluorescein labelled heteroantibodies and by their functional activities. The Ig fractions of horse and rabbit antisera to rat thymocytes, when labelled with fluorescein, stained more than 95% thymocytes, less than 2% bone marrow cells, and 30 to 60% of the lymphocytes in peripheral blood, lymph nodes and spleen, and did not stain IgG bearing lymphocytes. Cell mediated cytotoxicity and stimulation by PHA and Con A were eliminated by these heteroantisera and C in vitro and survival of skin allografts was prolonged in vivo. T lymphocytes in the rat resembled, by analogy, T lymphocytes in the mouse.
|Original language||English (US)|
|Number of pages||8|
|Journal||Journal of Immunology|
|State||Published - Jan 1 1974|
ASJC Scopus subject areas
- Immunology and Allergy