Thrombosis in myeloproliferative neoplasms: Update in pathophysiology

Brandi N. Reeves, Alison R. Moliterno

Research output: Contribution to journalReview articlepeer-review


Purpose of reviewThis review summarizes high-impact research in myeloproliferative neoplasms (MPN) from the last 18 months, with a particular focus on basic science findings.Recent findingsA pseudo-hypoxia state with stabilization of hypoxia-inducible factor (HIFα exists that is central to cell growth, cell renewal, inflammation, and thrombotic potential in MPN hematopoietic cells.SummaryHIFα and inflammatory pathways are new therapeutic targets in MPN, with the potential to ameliorate thrombotic risk and perhaps eradicate mutant progenitor cells.

Original languageEnglish (US)
Pages (from-to)285-291
Number of pages7
JournalCurrent opinion in hematology
Issue number5
StatePublished - Sep 1 2021


  • hypoxia-inducible factor
  • iron deficiency
  • myeloproliferative neoplasm
  • thromboinflammation

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Thrombosis in myeloproliferative neoplasms: Update in pathophysiology'. Together they form a unique fingerprint.

Cite this