TY - JOUR
T1 - Thrombosis in myeloproliferative neoplasms
T2 - Update in pathophysiology
AU - Reeves, Brandi N.
AU - Moliterno, Alison R.
N1 - Funding Information:
This work was supported by grants from the MPNRF (A.R.M.).
Publisher Copyright:
© 2021 Lippincott Williams and Wilkins. All rights reserved.
PY - 2021/9/1
Y1 - 2021/9/1
N2 - Purpose of reviewThis review summarizes high-impact research in myeloproliferative neoplasms (MPN) from the last 18 months, with a particular focus on basic science findings.Recent findingsA pseudo-hypoxia state with stabilization of hypoxia-inducible factor (HIFα exists that is central to cell growth, cell renewal, inflammation, and thrombotic potential in MPN hematopoietic cells.SummaryHIFα and inflammatory pathways are new therapeutic targets in MPN, with the potential to ameliorate thrombotic risk and perhaps eradicate mutant progenitor cells.
AB - Purpose of reviewThis review summarizes high-impact research in myeloproliferative neoplasms (MPN) from the last 18 months, with a particular focus on basic science findings.Recent findingsA pseudo-hypoxia state with stabilization of hypoxia-inducible factor (HIFα exists that is central to cell growth, cell renewal, inflammation, and thrombotic potential in MPN hematopoietic cells.SummaryHIFα and inflammatory pathways are new therapeutic targets in MPN, with the potential to ameliorate thrombotic risk and perhaps eradicate mutant progenitor cells.
KW - hypoxia-inducible factor
KW - iron deficiency
KW - myeloproliferative neoplasm
KW - thromboinflammation
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U2 - 10.1097/MOH.0000000000000664
DO - 10.1097/MOH.0000000000000664
M3 - Review article
C2 - 34183535
AN - SCOPUS:85114522274
SN - 1065-6251
VL - 28
SP - 285
EP - 291
JO - Current Opinion in Hematology
JF - Current Opinion in Hematology
IS - 5
ER -