Thrombolytic therapy in the setting of arterial line-induced ischemia

Jean François H. Geschwind, Mandeep S. Dagli, Drew L. Lambert, Hicham Kobeiter

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Purpose: To evaluate the use of percutaneous transcatheter thrombolysis in the treatment of thrombosis due to radial artery cannulation. Methods and Results: Seven patients (4 women; age range 41-62 years) with symptomatic cannulation-induced thrombosis and failure to improve after systemic anticoagulation underwent 8 catheter-directed thrombolytic infusions at our institution over a 3-year period. Access was either antegrade through the brachial artery or retrograde through the femoral artery. Thrombolytic infusions with urokinase began 2 to 12 days (average 6) after removal of the radial artery catheter. The thrombolytic infusion was successful in 5 of 7 patients based on angiographic flow restoration with <20% residual thrombus and significant clinical improvement in the ischemia. Conclusions: When systemic anticoagulation has failed, percutaneous catheter-directed thrombolytic infusion appears to be effective in the treatment of most patients with severe ischemic hand symptoms due to thrombosis after radial artery cannulation.

Original languageEnglish (US)
Pages (from-to)590-594
Number of pages5
JournalJournal of Endovascular Therapy
Issue number3
StatePublished - Jun 2003
Externally publishedYes


  • Catheterization
  • Complications
  • Hand ischemia
  • Iatrogenic injury
  • Radial artery
  • Thrombolysis
  • Thrombosis
  • Urokinase

ASJC Scopus subject areas

  • Surgery
  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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