Threshold phenomena and interactions between receptors

N. A. Flavahan; P. M. Vanhoutte

doi:10.1097/00005344-198800111-00015

Threshold phenomena and interactions between receptors

N. A. Flavahan, P. M. Vanhoutte

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Threshold or subthreshold concentrations of serotonin can augment contractile responses of isolated blood vessels to other vasoconstrictor agents. This report presents a theoretical analysis of threshold facilitation and concludes that the amplifying effect of serotonin may result from the removal of a response threshold. Physiological or pathophysiological alterations in the magnitude of this response threshold between different effector systems or in the efficacy of the vasoconstrictor agonist may account for the variability in the amplifying effect of serotonin observed in vivo and in vitro.

Original language	English (US)
Pages (from-to)	S67-S72
Journal	Journal of cardiovascular pharmacology
Volume	11
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1097/00005344-198800111-00015
State	Published - 1988
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Cardiology and Cardiovascular Medicine

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10.1097/00005344-198800111-00015

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AU - Vanhoutte, P. M.

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AB - Threshold or subthreshold concentrations of serotonin can augment contractile responses of isolated blood vessels to other vasoconstrictor agents. This report presents a theoretical analysis of threshold facilitation and concludes that the amplifying effect of serotonin may result from the removal of a response threshold. Physiological or pathophysiological alterations in the magnitude of this response threshold between different effector systems or in the efficacy of the vasoconstrictor agonist may account for the variability in the amplifying effect of serotonin observed in vivo and in vitro.

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Threshold phenomena and interactions between receptors

Abstract

ASJC Scopus subject areas

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