Three-way drug discrimination in post-addict volunteers: Hydromorphone, pentazocine, and saline

W. K. Bickel, K. L. Preston, G. E. Bigelow, I. A. Liebson

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The purpose of the present study was to establish in man a discrimination between pentazocine, the morphine-like drug hydromorphine, and saline using a three-choice drug discrimination procedure. In this procedure a discrimination is trained between the three drugs instead of the typical two-drug discrimination. Included in our adapted three-drug discrimination procedure are not only the operant discriminative performance, but other measures of discriminative performance, as well as subjective effect measures that have proven useful in describing the effects of the different drug classes. When combined with the traditional subjective measures, the drug discrimination procedure may result in finer and more complete descriptions of the interoceptive effects of psychoactive drugs.

Original languageEnglish (US)
Pages (from-to)177-183
Number of pages7
JournalNIDA Research Monograph Series
VolumeNO. 67
StatePublished - 1986

ASJC Scopus subject areas

  • Medicine (miscellaneous)


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