Three new diterpenoids from Leonurus japonicus

Zhi Ke Liu, Da Rong Wu, Yi Ming Shi, Ting Zeng, Shao Hua Liu, Xue Du, Yong Jun Dang, Wei Lie Xiao, Han Dong Sun

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Phytochemical investigation of the aerial parts of Leonurus japonicus led to the isolation of one unusual clerodane diterpenoid, leojaponin A (1), characterized by a C4-C7 oxa-bridge, and two new labdane diterpenoids, leojaponins B (2) and C (3). The structures of these new compounds were determined based on extensive 1D and 2D NMR spectroscopic data. To the best of our knowledge, compound 1 is the first clerodane diterpenoid obtained from Leonurus. japonicus. All of them were evaluated for their cytotoxicity.

Original languageEnglish (US)
Pages (from-to)677-679
Number of pages3
JournalChinese Chemical Letters
Issue number5
StatePublished - May 2014


  • Leojaponin A
  • Leojaponin B
  • Leojaponin C
  • Leonurus japonicus

ASJC Scopus subject areas

  • General Chemistry


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