Three new diterpenoids from Leonurus japonicus

Zhi Ke Liu; Da Rong Wu; Yi Ming Shi; Ting Zeng; Shao Hua Liu; Xue Du; Yong Jun Dang; Wei Lie Xiao; Han Dong Sun

doi:10.1016/j.cclet.2014.01.047

Three new diterpenoids from Leonurus japonicus

Zhi Ke Liu, Da Rong Wu, Yi Ming Shi, Ting Zeng, Shao Hua Liu, Xue Du, Yong Jun Dang, Wei Lie Xiao, Han Dong Sun

School of Medicine

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Phytochemical investigation of the aerial parts of Leonurus japonicus led to the isolation of one unusual clerodane diterpenoid, leojaponin A (1), characterized by a C₄-C₇ oxa-bridge, and two new labdane diterpenoids, leojaponins B (2) and C (3). The structures of these new compounds were determined based on extensive 1D and 2D NMR spectroscopic data. To the best of our knowledge, compound 1 is the first clerodane diterpenoid obtained from Leonurus. japonicus. All of them were evaluated for their cytotoxicity.

Original language	English (US)
Pages (from-to)	677-679
Number of pages	3
Journal	Chinese Chemical Letters
Volume	25
Issue number	5
DOIs	https://doi.org/10.1016/j.cclet.2014.01.047
State	Published - May 2014

Keywords

Leojaponin A
Leojaponin B
Leojaponin C
Leonurus japonicus

ASJC Scopus subject areas

Chemistry(all)

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10.1016/j.cclet.2014.01.047

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title = "Three new diterpenoids from Leonurus japonicus",

abstract = "Phytochemical investigation of the aerial parts of Leonurus japonicus led to the isolation of one unusual clerodane diterpenoid, leojaponin A (1), characterized by a C4-C7 oxa-bridge, and two new labdane diterpenoids, leojaponins B (2) and C (3). The structures of these new compounds were determined based on extensive 1D and 2D NMR spectroscopic data. To the best of our knowledge, compound 1 is the first clerodane diterpenoid obtained from Leonurus. japonicus. All of them were evaluated for their cytotoxicity.",

keywords = "Leojaponin A, Leojaponin B, Leojaponin C, Leonurus japonicus",

author = "Liu, {Zhi Ke} and Wu, {Da Rong} and Shi, {Yi Ming} and Ting Zeng and Liu, {Shao Hua} and Xue Du and Dang, {Yong Jun} and Xiao, {Wei Lie} and Sun, {Han Dong}",

note = "Funding Information: This project was supported financially by the Natural Science Foundation of Yunnan Province (No. 2012FB178 ) and the project sponsored by SRF for ROCS, SEM to W.L. Xiao. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "2014",

month = may,

doi = "10.1016/j.cclet.2014.01.047",

language = "English (US)",

volume = "25",

pages = "677--679",

journal = "Chinese Chemical Letters",

issn = "1001-8417",

publisher = "Elsevier",

number = "5",

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T1 - Three new diterpenoids from Leonurus japonicus

AU - Liu, Zhi Ke

AU - Wu, Da Rong

AU - Shi, Yi Ming

AU - Zeng, Ting

AU - Liu, Shao Hua

AU - Du, Xue

AU - Dang, Yong Jun

AU - Xiao, Wei Lie

AU - Sun, Han Dong

N1 - Funding Information: This project was supported financially by the Natural Science Foundation of Yunnan Province (No. 2012FB178 ) and the project sponsored by SRF for ROCS, SEM to W.L. Xiao. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 2014/5

Y1 - 2014/5

N2 - Phytochemical investigation of the aerial parts of Leonurus japonicus led to the isolation of one unusual clerodane diterpenoid, leojaponin A (1), characterized by a C4-C7 oxa-bridge, and two new labdane diterpenoids, leojaponins B (2) and C (3). The structures of these new compounds were determined based on extensive 1D and 2D NMR spectroscopic data. To the best of our knowledge, compound 1 is the first clerodane diterpenoid obtained from Leonurus. japonicus. All of them were evaluated for their cytotoxicity.

AB - Phytochemical investigation of the aerial parts of Leonurus japonicus led to the isolation of one unusual clerodane diterpenoid, leojaponin A (1), characterized by a C4-C7 oxa-bridge, and two new labdane diterpenoids, leojaponins B (2) and C (3). The structures of these new compounds were determined based on extensive 1D and 2D NMR spectroscopic data. To the best of our knowledge, compound 1 is the first clerodane diterpenoid obtained from Leonurus. japonicus. All of them were evaluated for their cytotoxicity.

KW - Leojaponin A

KW - Leojaponin B

KW - Leojaponin C

KW - Leonurus japonicus

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DO - 10.1016/j.cclet.2014.01.047

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SN - 1001-8417

VL - 25

SP - 677

EP - 679

JO - Chinese Chemical Letters

JF - Chinese Chemical Letters

IS - 5

ER -

Three new diterpenoids from Leonurus japonicus

Abstract

Keywords

ASJC Scopus subject areas

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