Three-dimensional volumetric assessment of diastolic function by cardiac magnetic resonance imaging: The multi-ethnic study of atherosclerosis (MESA)

Marcelo S. Nacif, Andre L.C. Almeida, Alistair A. Young, Brett R. Cowan, Anderson C. Armstrong, Eunice Yang, Christopher T. Sibley, W. Gregory Hundley, Songtao Liu, Joao A.C. Lima, David A. Bluemke

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Background: Cardiac Magnetic Resonance is in need of a simple and robust method for diastolic function assessment that can be done with routine protocol sequences. Objective: To develop and validate a three-dimensional (3D) model-based volumetric assessment of diastolic function using cardiac magnetic resonance (CMR) imaging and compare the results obtained with the model with those obtained by echocardiography. Methods: The study participants provided written informed consent and were included if having undergone both echocardiography and cine steady-state free precession (SSFP) CMR on the same day. Guide points at the septal and lateral mitral annulus were used to define the early longitudinal relaxation rate (E’), while a time-volume curve from the 3D model was used to assess diastolic filling parameters. We determined the correlation between 3D CMR and echocardiography and the accuracy of CMR in classifying the diastolic function grade. Results: The study included 102 subjects. The E/A ratio by CMR was positively associated with the E/A ratio by echocardiography (r = 0.71, p < 0.0001). The early diastolic relaxation velocity by tissue Doppler and longitudinal relaxation rate for the lateral mitral annulus displacement were positively associated (p = 0.007), as were the ratio between Doppler E/e’ and CMR E/E’ (p = 0.01). CMR-determined normalized peak E (NE) and deceleration time (DT) were able to predict diastolic dysfunction (areas under the curve [AUCs] = 0.70 and 0.72, respectively). In addition, the lateral E/E’ ratio showed good utility in identifying diastolic dysfunction (AUC = 0.80). Overall, echocardiography and CMR interobserver and intraobserver agreements were excellent (intraclass correlation coefficient range 0.72 – 0.97). Conclusion: 3D modeling of standard cine CMR images was able to identify study subjects with reduced diastolic function and showed good reproducibility, suggesting a potential for a routine diastolic function assessment by CMR.

Original languageEnglish (US)
Pages (from-to)552-563
Number of pages12
JournalArquivos brasileiros de cardiologia
Issue number6
StatePublished - Jun 2017


  • Echocardiography
  • Evaluation
  • Imaging three dimensional
  • Magnetic resonance
  • Three – dimensional
  • Ventricular function

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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