Three-dimensional printing of tissue phantoms for biophotonic imaging

Jianting Wang; James Coburn; Chia Pin Liang; Nicholas Woolsey; Jessica C. Ramella-Roman; Yu Chen; T. Joshua Pfefer

doi:10.1364/OL.39.003010

Three-dimensional printing of tissue phantoms for biophotonic imaging

Jianting Wang, James Coburn, Chia Pin Liang, Nicholas Woolsey, Jessica C. Ramella-Roman, Yu Chen, T. Joshua Pfefer

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

We have investigated the potential of tissue phantoms fabricated with thermosoftening- and photopolymerizationbased three-dimensional (3D) printers for use in evaluation of biophotonic imaging systems. The optical properties of printed polymer samples were measured and compared to biological tissues. Phantoms with subsurface channels as small as 0.2 mm in diameter were fabricated and imaged with microscopy, x-ray microtomography, and optical coherence tomography to characterize morphology. These phantoms were then implemented to evaluate the penetration depth of a hyperspectral reflectance imaging system used in conjunction with a near-infrared contrast agent. Results indicated that 3D printing may provide a suitable platform for performance testing in biophotonics, although subsurface imaging is critical to mitigate printer-to-printer variability in matrix homogeneity and feature microstructure.

Original language	English (US)
Pages (from-to)	3010-3013
Number of pages	4
Journal	Optics Letters
Volume	39
Issue number	10
DOIs	https://doi.org/10.1364/OL.39.003010
State	Published - May 15 2014
Externally published	Yes

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics
Medicine(all)

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10.1364/OL.39.003010

Cite this

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abstract = "We have investigated the potential of tissue phantoms fabricated with thermosoftening- and photopolymerizationbased three-dimensional (3D) printers for use in evaluation of biophotonic imaging systems. The optical properties of printed polymer samples were measured and compared to biological tissues. Phantoms with subsurface channels as small as 0.2 mm in diameter were fabricated and imaged with microscopy, x-ray microtomography, and optical coherence tomography to characterize morphology. These phantoms were then implemented to evaluate the penetration depth of a hyperspectral reflectance imaging system used in conjunction with a near-infrared contrast agent. Results indicated that 3D printing may provide a suitable platform for performance testing in biophotonics, although subsurface imaging is critical to mitigate printer-to-printer variability in matrix homogeneity and feature microstructure.",

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AU - Coburn, James

AU - Liang, Chia Pin

AU - Woolsey, Nicholas

AU - Ramella-Roman, Jessica C.

AU - Chen, Yu

AU - Joshua Pfefer, T.

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Three-dimensional printing of tissue phantoms for biophotonic imaging

Abstract

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