Three-dimensional functional magnetic resonance imaging of human brain on a clinical 1.5-T scanner

Peter Van Gelderen; Nick F. Ramsey; Guoying Liu; Jeff H. Duyn; Joseph A. Frank; Daniel R. Weinberger; Chrit T.W. Moonen

doi:10.1073/pnas.92.15.6906

Three-dimensional functional magnetic resonance imaging of human brain on a clinical 1.5-T scanner

Peter Van Gelderen, Nick F. Ramsey, Guoying Liu, Jeff H. Duyn, Joseph A. Frank, Daniel R. Weinberger, Chrit T.W. Moonen

Research output: Contribution to journal › Article › peer-review

130 Scopus citations

Abstract

Functional magnetic resonance imaging (fMRI) is a tool for mapping brain function that utilizes neuronal activity-induced changes in blood oxygenation. An efficient three-dimensional fMR1 method is presented for imaging brain activity on conventional, widely available, 1.5-T scanners, without additional hardware. This approach uses large magnetic susceptibility weighting based on the echo-shifting principle combined with multiple gradient echoes per excitation. Motor stimulation, induced by self-paced finger tapping, reliably produced significant signal increase in the hand region of the contralateral primary motor cortex in every subject tested.

Original language	English (US)
Pages (from-to)	6906-6910
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	92
Issue number	15
DOIs	https://doi.org/10.1073/pnas.92.15.6906
State	Published - Jul 18 1995
Externally published	Yes

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title = "Three-dimensional functional magnetic resonance imaging of human brain on a clinical 1.5-T scanner",

abstract = "Functional magnetic resonance imaging (fMRI) is a tool for mapping brain function that utilizes neuronal activity-induced changes in blood oxygenation. An efficient three-dimensional fMR1 method is presented for imaging brain activity on conventional, widely available, 1.5-T scanners, without additional hardware. This approach uses large magnetic susceptibility weighting based on the echo-shifting principle combined with multiple gradient echoes per excitation. Motor stimulation, induced by self-paced finger tapping, reliably produced significant signal increase in the hand region of the contralateral primary motor cortex in every subject tested.",

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AU - Van Gelderen, Peter

AU - Ramsey, Nick F.

AU - Liu, Guoying

AU - Duyn, Jeff H.

AU - Frank, Joseph A.

AU - Weinberger, Daniel R.

AU - Moonen, Chrit T.W.

PY - 1995/7/18

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N2 - Functional magnetic resonance imaging (fMRI) is a tool for mapping brain function that utilizes neuronal activity-induced changes in blood oxygenation. An efficient three-dimensional fMR1 method is presented for imaging brain activity on conventional, widely available, 1.5-T scanners, without additional hardware. This approach uses large magnetic susceptibility weighting based on the echo-shifting principle combined with multiple gradient echoes per excitation. Motor stimulation, induced by self-paced finger tapping, reliably produced significant signal increase in the hand region of the contralateral primary motor cortex in every subject tested.

AB - Functional magnetic resonance imaging (fMRI) is a tool for mapping brain function that utilizes neuronal activity-induced changes in blood oxygenation. An efficient three-dimensional fMR1 method is presented for imaging brain activity on conventional, widely available, 1.5-T scanners, without additional hardware. This approach uses large magnetic susceptibility weighting based on the echo-shifting principle combined with multiple gradient echoes per excitation. Motor stimulation, induced by self-paced finger tapping, reliably produced significant signal increase in the hand region of the contralateral primary motor cortex in every subject tested.

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Three-dimensional functional magnetic resonance imaging of human brain on a clinical 1.5-T scanner

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