Three-Dimensional CT Morphometric Image Analysis of the Clivus and Sphenoid Sinus in Chiari Malformation Type I

Blaise Simplice Talla Nwotchouang, Maggie S. Eppelheimer, Paul Bishop, Dipankar Biswas, Janna M. Andronowski, Jayapalli R. Bapuraj, David Frim, Rick Labuda, Rouzbeh Amini, Francis Loth

Research output: Contribution to journalArticlepeer-review


This study evaluated three-dimensional (3D) volumetric image reconstructions to identify morphological differences of the clivus and sphenoid sinus on computed tomography (CT) scans of Chiari malformation type I (CMI) and control subjects. Axial CT images of adult females for 30 CMI subjects and 30 age and body mass index (BMI) matched controls were used for this retrospective study. 3D volumetric reconstructions were created from the bone windows of axial data following image registration for position and orientation correction of the head. The volume, surface area, linear dimensions and spatial position in the x, y, and z-axes were computed separately for the clivus and the sphenoid sinus for each subject. Eleven parameters were found to be significantly different between CMI subjects compared to controls. Most notably, clivus volume was reduced by 31% on average in CMI subjects. In contrast, we found that the sphenoid sinus volume was 38% greater on average in CMI subjects. Moreover, clivus length, height, width, and thickness were 3.7, 2.8, 3.0 and 9.4 mm reduced, respectively, in CMI subjects. This is the first study to demonstrate cephalometric differences in the 3D morphology of the clivus and sphenoid sinus between CMI subjects and controls.

Original languageEnglish (US)
Pages (from-to)2284-2295
Number of pages12
JournalAnnals of biomedical engineering
Issue number11
StatePublished - Nov 1 2019
Externally publishedYes


  • 3D image registration
  • Chiari
  • Clivus
  • Osseous
  • Posterior cranial fossa
  • Sella turcica
  • Tonsillar position

ASJC Scopus subject areas

  • Biomedical Engineering


Dive into the research topics of 'Three-Dimensional CT Morphometric Image Analysis of the Clivus and Sphenoid Sinus in Chiari Malformation Type I'. Together they form a unique fingerprint.

Cite this