Three-dimensional cell cultures as a model system to evaluate the biological activity of gemcitabine (2',2'-difluoro-2'deoxycytidine)

G. J. Peters; E. Smitskamp-Wilms; G. Veerman; P. E. Pizao; V. W T Ruiz van Haperen; H. M. Pinedo

Three-dimensional cell cultures as a model system to evaluate the biological activity of gemcitabine (2',2'-difluoro-2'deoxycytidine)

G. J. Peters
, E. Smitskamp-Wilms
, G. Veerman
, P. E. Pizao
, V. W T Ruiz van Haperen
, H. M. Pinedo

Research output: Contribution to journal › Article › peer-review

Abstract

The cytotoxicity of Gemcitabine (dFdC) was 10 (ovarian cancer) to > 10,000 (colon cancer) fold higher in monolayer compared to three-dimensional multilayer cell cultures. This selectivity was related to marked differences in dFdC activation and effects on ribonucleotides.

Original language	English (US)
Pages (from-to)	661-664
Number of pages	4
Journal	Nucleosides and Nucleotides
Volume	14
Issue number	3-5
State	Published - 1995
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Genetics

Cite this

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title = "Three-dimensional cell cultures as a model system to evaluate the biological activity of gemcitabine (2',2'-difluoro-2'deoxycytidine)",

abstract = "The cytotoxicity of Gemcitabine (dFdC) was 10 (ovarian cancer) to > 10,000 (colon cancer) fold higher in monolayer compared to three-dimensional multilayer cell cultures. This selectivity was related to marked differences in dFdC activation and effects on ribonucleotides.",

author = "Peters, \{G. J.\} and E. Smitskamp-Wilms and G. Veerman and Pizao, \{P. E.\} and \{Ruiz van Haperen\}, \{V. W T\} and Pinedo, \{H. M.\}",

year = "1995",

language = "English (US)",

volume = "14",

pages = "661--664",

journal = "Nucleosides and Nucleotides",

issn = "0732-8311",

publisher = "Marcel Dekker Inc.",

number = "3-5",

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TY - JOUR

T1 - Three-dimensional cell cultures as a model system to evaluate the biological activity of gemcitabine (2',2'-difluoro-2'deoxycytidine)

AU - Peters, G. J.

AU - Smitskamp-Wilms, E.

AU - Veerman, G.

AU - Pizao, P. E.

AU - Ruiz van Haperen, V. W T

AU - Pinedo, H. M.

PY - 1995

Y1 - 1995

N2 - The cytotoxicity of Gemcitabine (dFdC) was 10 (ovarian cancer) to > 10,000 (colon cancer) fold higher in monolayer compared to three-dimensional multilayer cell cultures. This selectivity was related to marked differences in dFdC activation and effects on ribonucleotides.

AB - The cytotoxicity of Gemcitabine (dFdC) was 10 (ovarian cancer) to > 10,000 (colon cancer) fold higher in monolayer compared to three-dimensional multilayer cell cultures. This selectivity was related to marked differences in dFdC activation and effects on ribonucleotides.

UR - https://www.scopus.com/pages/publications/0029064670

UR - https://www.scopus.com/pages/publications/0029064670#tab=citedBy

M3 - Article

AN - SCOPUS:0029064670

SN - 0732-8311

VL - 14

SP - 661

EP - 664

JO - Nucleosides and Nucleotides

JF - Nucleosides and Nucleotides

IS - 3-5

ER -

Three-dimensional cell cultures as a model system to evaluate the biological activity of gemcitabine (2',2'-difluoro-2'deoxycytidine)

Abstract

ASJC Scopus subject areas

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