| Original language | English (US) |
|---|---|
| Pages (from-to) | S379-383 |
| Journal | Academic radiology |
| Volume | 3 Suppl 2 |
| DOIs | |
| State | Published - Aug 1996 |
| Externally published | Yes |
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
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In: Academic radiology, Vol. 3 Suppl 2, 08.1996, p. S379-383.
Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Three-dimensional "BURST" functional magnetic resonance imaging
T2 - initial clinical applications.
AU - Mattay, V. S.
AU - Frank, J. A.
AU - Duyn, J. H.
AU - Kotrla, K. J.
AU - Santha, A. K.
AU - Esposito, G.
AU - Sexton, R. H.
AU - Barker, P.
AU - Sunderland, T.
AU - Moonen, C. T.
AU - Weinberger, D. R.
N1 - Funding Information: This study was approved by the Intramural Review Board of the National Institute of blental Health at the National Institutes of Health and the Joint Committee for Clinical Investigation of the Johns Hopkins School of Medicine. We studied four young healthy volunteers (mean age -~ 25 years), six older heahhy volunteers age matched to' the patients with senile dementia of the Alzheimer's. type (SDAT; mean age = 71 years), six patients with SDAT (mean age = 70 years), two patients with high-grade carotid artery stenosis (one 56-year-old man with stenosis of the right carotid artery and one 60-year-old woman with stenosis of the left carotid artery), and one 39-year-old woman with a subacute cerebral infarction in the distribution of the left middle cerebral artery (MCA). Imaging was done on a Signa 1.5-T scanner (General Electric Medical Systems, Milwaukee, WI) using a standard quadrature head coil and shielded gradients. The FS-BURST pulse sequence \[12\]h as an effective echo time (TE) of 28.8 msec and a repetition time (TR) of 45 msec. SLxty three-dimensional whole-brain volumes, each with 48 oblique (coronoaxial) slices, were acquired in approximately 2 min 12 sec. After 10 baseline volumes were acquired, 0.13 mmol/kg of gadopentetate dimeglumine (Magnevist; Berlex L'lboratodes, \X~ayne, NJ) was administered intravenously as a bolus in all subjects except the patient with subacute infarction of the left MCA. The bolus was administered at 6 ml/sec via a mechanical injector (Medrad, Pittsburgh, PA) through an 18-gauge catheter placed in an antecubital vein. The total injection time was usually 3~-5 sec. In the patient with subacute infarction of the left MCA,.a 0.15 nm~ol/kg dose was injected manually within 6-10"sec. Vital signs were monitored, and a questionnaire was given to all subjects to record side effects from the bolus administration of contrast material. All six p~ttients with SDAT also underwent SPECT-hexamethyli~ropyleneamine oxime (HMPAO) scans of cerebral blood flow. The scans were acquired on a dedicated head scanner (Ceraspect; DSI, Wahham, MA) equipped with a high-resolution collimator, yielding an image resolution of approximately 7.'5 mm full width at half-maximun~ intensity. Each patient received approximately 10 mCi of 99mTc-HMPAO intravenously 10 min before data acquisition. Scans were acquired during a 20-rain period.
PY - 1996/8
Y1 - 1996/8
UR - http://www.scopus.com/inward/record.url?scp=0030209986&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030209986&partnerID=8YFLogxK
U2 - 10.1016/s1076-6332(96)80590-3
DO - 10.1016/s1076-6332(96)80590-3
M3 - Article
C2 - 8796608
AN - SCOPUS:0030209986
SN - 1076-6332
VL - 3 Suppl 2
SP - S379-383
JO - Academic radiology
JF - Academic radiology
ER -