Thirteen X-chromosomal short tandem repeat loci multiplex data from Taiwanese

Hsiao Lin Hwa; Yih Yuan Chang; James Chun I Lee; Hsiang Yi Yin; Ya Hui Chen; Li Hui Tseng; Yi Ning Su; Tsang Ming Ko

doi:10.1007/s00414-008-0310-y

Thirteen X-chromosomal short tandem repeat loci multiplex data from Taiwanese

Hsiao Lin Hwa, Yih Yuan Chang, James Chun I Lee, Hsiang Yi Yin, Ya Hui Chen, Li Hui Tseng, Yi Ning Su, Tsang Ming Ko

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Study results of variations in the X chromosome are useful tools in researching the genetic diversity of human populations and individual identification. We developed a 13 X chromosomal short tandem repeat (STR) multiplex system (DXS6807, DXS8378, DSX9902, DXS7132, DXS9898, DXS6809, DXS6789, DXS7424, DXS101, GATA172D05, HPRTB, DXS8377, DXS7423) amplified in one single polymerase chain reaction. DNA samples of 113 male and 108 female Taiwanese Han subjects were successfully analyzed using this 13 X-STR multiplex system. The distributions of allele frequencies were examined for independence. DXS8377, DXS101, DXS6789, and DXS6809 were found to be the most polymorphic markers in this study. High values of discrimination power and mean exclusion chance without significant evidence of association between these markers were obtained. In conclusion, this 13 X chromosomal STR multiplex system offers considerable forensic efficiency and may be useful in forensic identification casework.

Original language	English (US)
Pages (from-to)	263-269
Number of pages	7
Journal	International Journal of Legal Medicine
Volume	123
Issue number	3
DOIs	https://doi.org/10.1007/s00414-008-0310-y
State	Published - May 2009
Externally published	Yes

Keywords

Forensic identification
Multiplex PCR
Short tandem repeat
X chromosome

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1007/s00414-008-0310-y

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title = "Thirteen X-chromosomal short tandem repeat loci multiplex data from Taiwanese",

abstract = "Study results of variations in the X chromosome are useful tools in researching the genetic diversity of human populations and individual identification. We developed a 13 X chromosomal short tandem repeat (STR) multiplex system (DXS6807, DXS8378, DSX9902, DXS7132, DXS9898, DXS6809, DXS6789, DXS7424, DXS101, GATA172D05, HPRTB, DXS8377, DXS7423) amplified in one single polymerase chain reaction. DNA samples of 113 male and 108 female Taiwanese Han subjects were successfully analyzed using this 13 X-STR multiplex system. The distributions of allele frequencies were examined for independence. DXS8377, DXS101, DXS6789, and DXS6809 were found to be the most polymorphic markers in this study. High values of discrimination power and mean exclusion chance without significant evidence of association between these markers were obtained. In conclusion, this 13 X chromosomal STR multiplex system offers considerable forensic efficiency and may be useful in forensic identification casework.",

keywords = "Forensic identification, Multiplex PCR, Short tandem repeat, X chromosome",

author = "Hwa, {Hsiao Lin} and Chang, {Yih Yuan} and Lee, {James Chun I} and Yin, {Hsiang Yi} and Chen, {Ya Hui} and Tseng, {Li Hui} and Su, {Yi Ning} and Ko, {Tsang Ming}",

year = "2009",

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doi = "10.1007/s00414-008-0310-y",

language = "English (US)",

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T1 - Thirteen X-chromosomal short tandem repeat loci multiplex data from Taiwanese

AU - Hwa, Hsiao Lin

AU - Chang, Yih Yuan

AU - Lee, James Chun I

AU - Yin, Hsiang Yi

AU - Chen, Ya Hui

AU - Tseng, Li Hui

AU - Su, Yi Ning

AU - Ko, Tsang Ming

PY - 2009/5

Y1 - 2009/5

N2 - Study results of variations in the X chromosome are useful tools in researching the genetic diversity of human populations and individual identification. We developed a 13 X chromosomal short tandem repeat (STR) multiplex system (DXS6807, DXS8378, DSX9902, DXS7132, DXS9898, DXS6809, DXS6789, DXS7424, DXS101, GATA172D05, HPRTB, DXS8377, DXS7423) amplified in one single polymerase chain reaction. DNA samples of 113 male and 108 female Taiwanese Han subjects were successfully analyzed using this 13 X-STR multiplex system. The distributions of allele frequencies were examined for independence. DXS8377, DXS101, DXS6789, and DXS6809 were found to be the most polymorphic markers in this study. High values of discrimination power and mean exclusion chance without significant evidence of association between these markers were obtained. In conclusion, this 13 X chromosomal STR multiplex system offers considerable forensic efficiency and may be useful in forensic identification casework.

AB - Study results of variations in the X chromosome are useful tools in researching the genetic diversity of human populations and individual identification. We developed a 13 X chromosomal short tandem repeat (STR) multiplex system (DXS6807, DXS8378, DSX9902, DXS7132, DXS9898, DXS6809, DXS6789, DXS7424, DXS101, GATA172D05, HPRTB, DXS8377, DXS7423) amplified in one single polymerase chain reaction. DNA samples of 113 male and 108 female Taiwanese Han subjects were successfully analyzed using this 13 X-STR multiplex system. The distributions of allele frequencies were examined for independence. DXS8377, DXS101, DXS6789, and DXS6809 were found to be the most polymorphic markers in this study. High values of discrimination power and mean exclusion chance without significant evidence of association between these markers were obtained. In conclusion, this 13 X chromosomal STR multiplex system offers considerable forensic efficiency and may be useful in forensic identification casework.

KW - Forensic identification

KW - Multiplex PCR

KW - Short tandem repeat

KW - X chromosome

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Thirteen X-chromosomal short tandem repeat loci multiplex data from Taiwanese

Abstract

Keywords

ASJC Scopus subject areas

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