Thermodynamic and kinetic studies of a stoichiometric model of energetic metabolism under starvation conditions

Sonia Cortassa; Miguel A. Aon; Daniel Thomas

doi:10.1016/0378-1097(90)90292-X

Thermodynamic and kinetic studies of a stoichiometric model of energetic metabolism under starvation conditions

Sonia Cortassa, Miguel A. Aon, Daniel Thomas

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

A stoichiometric model of anaerobic glycolysis is presented and the influence on its dynamics by the ATP-consuming membrane transport processes and substrate input rate are studied. The model is represented by a system of four ODE (ordinary differential equations), mass conservation equations and functions of state variables, such as thermodynamic efficiency. A low substrate input rate provokes damped oscillations while a high enrgy load determines sustained oscillations in all the metabolites and in thermodynamic efficiency. Due to the lack of linearity between fluxes and forces in the oscillatory region it may be stated that oscillations appear when the system is kinetically controlled.

Original language	English (US)
Pages (from-to)	249-255
Number of pages	7
Journal	FEMS microbiology letters
Volume	66
Issue number	1-3
DOIs	https://doi.org/10.1016/0378-1097(90)90292-X
State	Published - Jan 1 1990
Externally published	Yes

Keywords

Anaerobic glycolysis
Kinetic/thermodynamic control
Oscillations
Starvation

ASJC Scopus subject areas

Microbiology
Molecular Biology
Genetics

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10.1016/0378-1097(90)90292-X

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title = "Thermodynamic and kinetic studies of a stoichiometric model of energetic metabolism under starvation conditions",

abstract = "A stoichiometric model of anaerobic glycolysis is presented and the influence on its dynamics by the ATP-consuming membrane transport processes and substrate input rate are studied. The model is represented by a system of four ODE (ordinary differential equations), mass conservation equations and functions of state variables, such as thermodynamic efficiency. A low substrate input rate provokes damped oscillations while a high enrgy load determines sustained oscillations in all the metabolites and in thermodynamic efficiency. Due to the lack of linearity between fluxes and forces in the oscillatory region it may be stated that oscillations appear when the system is kinetically controlled.",

keywords = "Anaerobic glycolysis, Kinetic/thermodynamic control, Oscillations, Starvation",

author = "Sonia Cortassa and Aon, {Miguel A.} and Daniel Thomas",

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T1 - Thermodynamic and kinetic studies of a stoichiometric model of energetic metabolism under starvation conditions

AU - Cortassa, Sonia

AU - Aon, Miguel A.

AU - Thomas, Daniel

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Y1 - 1990/1/1

N2 - A stoichiometric model of anaerobic glycolysis is presented and the influence on its dynamics by the ATP-consuming membrane transport processes and substrate input rate are studied. The model is represented by a system of four ODE (ordinary differential equations), mass conservation equations and functions of state variables, such as thermodynamic efficiency. A low substrate input rate provokes damped oscillations while a high enrgy load determines sustained oscillations in all the metabolites and in thermodynamic efficiency. Due to the lack of linearity between fluxes and forces in the oscillatory region it may be stated that oscillations appear when the system is kinetically controlled.

AB - A stoichiometric model of anaerobic glycolysis is presented and the influence on its dynamics by the ATP-consuming membrane transport processes and substrate input rate are studied. The model is represented by a system of four ODE (ordinary differential equations), mass conservation equations and functions of state variables, such as thermodynamic efficiency. A low substrate input rate provokes damped oscillations while a high enrgy load determines sustained oscillations in all the metabolites and in thermodynamic efficiency. Due to the lack of linearity between fluxes and forces in the oscillatory region it may be stated that oscillations appear when the system is kinetically controlled.

KW - Anaerobic glycolysis

KW - Kinetic/thermodynamic control

KW - Oscillations

KW - Starvation

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JF - FEMS microbiology letters

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ER -

Thermodynamic and kinetic studies of a stoichiometric model of energetic metabolism under starvation conditions

Abstract

Keywords

ASJC Scopus subject areas

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