Thermal Inactivation of Human Norovirus Surrogates

Kristen E. Gibson, Kellogg J. Schwab

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


We investigated the thermal inactivation profiles of murine norovirus (MNV), Hepatitis A virus (HAV), and feline calicivirus (FCV), which are surrogates for the study of human noroviruses. Thermal inactivation of MNV and FCV were evaluated at 37, 50, and 60°C and HAV at 37, 50, 60, and 70°C. All viral surrogates were relatively stable at 37°C. MNV and FCV decimal reduction times (D-values) at 50°C were statistically significantly different (P < 0.05) with MNV being more stable. Both surrogates had comparable, low D-values at 60°C. HAV had significantly higher (P < 0.05) D-values than both MNV and FCV at 50 and 60°C. Overall, the infectivity assay results indicate that HAV is resistant to thermal inactivation while MNV is moderately resistant and FCV is least resistant.

Original languageEnglish (US)
Pages (from-to)74-77
Number of pages4
JournalFood and Environmental Virology
Issue number2
StatePublished - Jun 2011


  • Feline calicivirus
  • Murine norovirus
  • Norovirus
  • Surrogate
  • Thermal inactivation

ASJC Scopus subject areas

  • Epidemiology
  • Food Science
  • Health, Toxicology and Mutagenesis
  • Virology


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