Therapy-related acute leukemia

J. E. Karp; C. B. Sarkodee-Adoo

doi:10.1016/s0272-2712(18)30077-5

Therapy-related acute leukemia

J. E. Karp, C. B. Sarkodee-Adoo

Research output: Contribution to journal › Review article › peer-review

26 Scopus citations

Abstract

Acute leukemias that arise as a result of treatment with DNA-damaging agents exhibit distinctive molecular, genetic, and clinico-pathologic features. In this timely article, the authors dissect the pathogenetic basis of therapy-related leukemias, elucidating important molecular mechanisms through which DNA damage causes these disorders. The authors also discuss how these molecular aberrations translate into specific clinical syndromes, and in addition, point out potential molecular targets for the development of innovative treatment approaches.

Original language	English (US)
Pages (from-to)	71-81
Number of pages	11
Journal	Clinics in laboratory medicine
Volume	20
Issue number	1
DOIs	https://doi.org/10.1016/s0272-2712(18)30077-5
State	Published - 2000
Externally published	Yes

ASJC Scopus subject areas

Clinical Biochemistry
Biochemistry, medical

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10.1016/s0272-2712(18)30077-5

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AU - Sarkodee-Adoo, C. B.

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AB - Acute leukemias that arise as a result of treatment with DNA-damaging agents exhibit distinctive molecular, genetic, and clinico-pathologic features. In this timely article, the authors dissect the pathogenetic basis of therapy-related leukemias, elucidating important molecular mechanisms through which DNA damage causes these disorders. The authors also discuss how these molecular aberrations translate into specific clinical syndromes, and in addition, point out potential molecular targets for the development of innovative treatment approaches.

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Therapy-related acute leukemia

Abstract

ASJC Scopus subject areas

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