Therapeutic vaccines for cancer: An overview of clinical trials

Ignacio Melero, Gustav Gaudernack, Winald Gerritsen, Christoph Huber, Giorgio Parmiani, Suzy Scholl, Nicholas Thatcher, John Wagstaff, Christoph Zielinski, Ian Faulkner, Håkan Mellstedt

Research output: Contribution to journalArticlepeer-review

443 Scopus citations


The therapeutic potential of host-specific and tumour-specific immune responses is well recognized and, after many years, active immunotherapies directed at inducing or augmenting these responses are entering clinical practice. Antitumour immunization is a complex, multi-component task, and the optimal combinations of antigens, adjuvants, delivery vehicles and routes of administration are not yet identified. Active immunotherapy must also address the immunosuppressive and tolerogenic mechanisms deployed by tumours. This Review provides an overview of new results from clinical studies of therapeutic cancer vaccines directed against tumour-associated antigens and discusses their implications for the use of active immunotherapy.

Original languageEnglish (US)
Pages (from-to)509-524
Number of pages16
JournalNature Reviews Clinical Oncology
Issue number9
StatePublished - 2014
Externally publishedYes

ASJC Scopus subject areas

  • Oncology


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