Theranostic small interfering RNA nanoparticles in cancer precision nanomedicine

Zhihang Chen, Balaji Krishnamachary, Jesus Pachecho-Torres, Marie France Penet, Zaver M. Bhujwalla

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Due to their ability to effectively downregulate the expression of target genes, small interfering RNA (siRNA) have emerged as promising candidates for precision medicine in cancer. Although some siRNA-based treatments have advanced to clinical trials, challenges such as poor stability during circulation, and less than optimal pharmacokinetics and biodistribution of siRNA in vivo present barriers to the systemic delivery of siRNA. In recent years, theranostic nanomedicine integrating siRNA delivery has attracted significant attention for precision medicine. Theranostic nanomedicine takes advantage of the high capacity of nanoplatforms to ferry cargo with imaging and therapeutic capabilities. These theranostic nanoplatforms have the potential to play a major role in gene specific treatments. Here we have reviewed recent advances in the use of theranostic nanoplatforms to deliver siRNA, and discussed the opportunities as well as challenges associated with this exciting technology. This article is categorized under: Diagnostic Tools > In Vivo Nanodiagnostics and Imaging Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Implantable Materials and Surgical Technologies > Nanomaterials and Implants.

Original languageEnglish (US)
Article numbere1595
JournalWiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
Issue number2
StatePublished - Mar 1 2020


  • cancer
  • molecular imaging
  • nanomedicine
  • siRNA
  • theranostics

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering
  • Medicine (miscellaneous)


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